Literature DB >> 22519513

The solute carrier 6 family of transporters.

Stefan Bröer1, Ulrik Gether.   

Abstract

The solute carrier 6 (SLC6) family of the human genome comprises transporters for neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family play critical roles in neurotransmission, cellular and whole body homeostasis. Malfunction or altered expression of these transporters is associated with a variety of diseases. Pharmacological inhibition of the neurotransmitter transporters in this family is an important strategy in the management of neurological and psychiatric disorders. This review provides an overview of the biochemical and pharmacological properties of the SLC6 family transporters.
© 2012 The Authors. British Journal of Pharmacology © 2012 The British Pharmacological Society.

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Year:  2012        PMID： 22519513      PMCID： PMC3481037          DOI： 10.1111/j.1476-5381.2012.01975.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  232 in total

Review 1.  Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters.

Authors:  Jacob Andersen; Anders S Kristensen; Benny Bang-Andersen; Kristian Strømgaard
Journal:  Chem Commun (Camb)       Date:  2009-05-07       Impact factor: 6.222

Review 2.  Glycine transport inhibitors for the treatment of schizophrenia: symptom and disease modification.

Authors:  Daniel C Javitt
Journal:  Curr Opin Drug Discov Devel       Date:  2009-07

Review 3.  The rocking bundle: a mechanism for ion-coupled solute flux by symmetrical transporters.

Authors:  Lucy R Forrest; Gary Rudnick
Journal:  Physiology (Bethesda)       Date:  2009-12

4.  Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis.

Authors:  Neil Risch; Richard Herrell; Thomas Lehner; Kung-Yee Liang; Lindon Eaves; Josephine Hoh; Andrea Griem; Maria Kovacs; Jurg Ott; Kathleen Ries Merikangas
Journal:  JAMA       Date:  2009-06-17       Impact factor: 56.272

5.  Glycine transporter inhibitors as a novel drug discovery strategy for neuropathic pain.

Authors:  Toshihiro Dohi; Katsuya Morita; Tomoya Kitayama; Naoyo Motoyama; Norimitsu Morioka
Journal:  Pharmacol Ther       Date:  2009-04-23       Impact factor: 12.310

Review 6.  Structure and function of Na(+)-symporters with inverted repeats.

Authors:  Jeff Abramson; Ernest M Wright
Journal:  Curr Opin Struct Biol       Date:  2009-07-22       Impact factor: 6.809

7.  Association of major depression with rare functional variants in norepinephrine transporter and serotonin1A receptor genes.

Authors:  Britta Haenisch; Karoline Linsel; Michael Brüss; Ralf Gilsbach; Peter Propping; Markus M Nöthen; Marcella Rietschel; Rolf Fimmers; Wolfgang Maier; Astrid Zobel; Susanne Höfels; Vera Guttenthaler; Manfred Göthert; Heinz Bönisch
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2009-10-05       Impact factor: 3.568

8.  Orphan transporter SLC6A18 is renal neutral amino acid transporter B0AT3.

Authors:  Dustin Singer; Simone M R Camargo; Katja Huggel; Elisa Romeo; Ursula Danilczyk; Keiji Kuba; Serge Chesnov; Marc G Caron; Josef M Penninger; Francois Verrey
Journal:  J Biol Chem       Date:  2009-05-28       Impact factor: 5.157

9.  Homozygous loss-of-function mutations in the gene encoding the dopamine transporter are associated with infantile parkinsonism-dystonia.

Authors:  Manju A Kurian; Juan Zhen; Shu-Yuan Cheng; Yan Li; Santosh R Mordekar; Philip Jardine; Neil V Morgan; Esther Meyer; Louise Tee; Shanaz Pasha; Evangeline Wassmer; Simon J R Heales; Paul Gissen; Maarten E A Reith; Eamonn R Maher
Journal:  J Clin Invest       Date:  2009-05-26       Impact factor: 14.808

10.  Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.

Authors:  Zheng Zhou; Juan Zhen; Nathan K Karpowich; Christopher J Law; Maarten E A Reith; Da-Neng Wang
Journal:  Nat Struct Mol Biol       Date:  2009-05-10       Impact factor: 15.369
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  87 in total

1.  SNF-10 connects male-derived signals to the onset of sperm motility in C. elegans.

Authors:  Kristin E Fenker; Gillian M Stanfield
Journal:  Worm       Date:  2015-01-29

2.  Differential Internalization Rates and Postendocytic Sorting of the Norepinephrine and Dopamine Transporters Are Controlled by Structural Elements in the N Termini.

Authors:  Anne Vuorenpää; Trine N Jørgensen; Amy H Newman; Kenneth L Madsen; Mika Scheinin; Ulrik Gether
Journal:  J Biol Chem       Date:  2016-01-19       Impact factor: 5.157

Review 3.  Connections between preimplantation embryo physiology and culture.

Authors:  Jay M Baltz
Journal:  J Assist Reprod Genet       Date:  2013-08       Impact factor: 3.412

4.  Dopamine transporter endocytic trafficking in striatal dopaminergic neurons: differential dependence on dynamin and the actin cytoskeleton.

Authors:  Luke R Gabriel; Sijia Wu; Patrick Kearney; Karl D Bellvé; Clive Standley; Kevin E Fogarty; Haley E Melikian
Journal:  J Neurosci       Date:  2013-11-06       Impact factor: 6.167

Review 5.  The SLC38 family of sodium-amino acid co-transporters.

Authors:  Stefan Bröer
Journal:  Pflugers Arch       Date:  2013-11-06       Impact factor: 3.657

Review 6.  Functional mechanisms of neurotransmitter transporters regulated by lipid-protein interactions of their terminal loops.

Authors:  George Khelashvili; Harel Weinstein
Journal:  Biochim Biophys Acta       Date:  2015-04-04

7.  Four novel interaction partners demonstrate diverse modulatory effects on voltage-gated CaV2.2 Ca2+ channels.

Authors:  Robert Mallmann; Katarina Ondacova; Lucia Moravcikova; Bohumila Jurkovicova-Tarabova; Michaela Pavlovicova; Roman Moravcik; Lucia Lichvarova; Viera Kominkova; Norbert Klugbauer; Lubica Lacinova
Journal:  Pflugers Arch       Date:  2019-01-05       Impact factor: 3.657

8.  Structural elements required for coupling ion and substrate transport in the neurotransmitter transporter homolog LeuT.

Authors:  Yuan-Wei Zhang; Sotiria Tavoulari; Steffen Sinning; Antoniya A Aleksandrova; Lucy R Forrest; Gary Rudnick
Journal:  Proc Natl Acad Sci U S A       Date:  2018-09-04       Impact factor: 11.205

9.  The Concise Guide to PHARMACOLOGY 2013/14: transporters.

Authors:  Stephen P H Alexander; Helen E Benson; Elena Faccenda; Adam J Pawson; Joanna L Sharman; Michael Spedding; John A Peters; Anthony J Harmar
Journal:  Br J Pharmacol       Date:  2013-12       Impact factor: 8.739

10.  Serotonin-induced down-regulation of cell surface serotonin transporter.

Authors:  Trine Nygaard Jørgensen; Peter Møller Christensen; Ulrik Gether
Journal:  Neurochem Int       Date:  2014-01-22       Impact factor: 3.921
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