| Literature DB >> 809293 |
Abstract
The antithyroid drug, methimazole (1-methyl-2-thiolimidazole), is a powerful chelator of cupric ion. This is reflected in its ability to selectively inhibit certain copper oxidases. Uricase, ascorbic oxidase and monoamine oxidase are not affected. Ceruloplasmin oxidase is slightly inhibited and tyrosinase is markedly inhibited by methimazole.Entities:
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Year: 1975 PMID： 809293 DOI： 10.1007/BF02326924
Source DB: PubMed Journal: Experientia ISSN： 0014-4754