Literature DB >> 3141207

Inhibition of mushroom tyrosinase by 3-amino-L-tyrosine: molecular probing of the active site of the enzyme.

J F Maddaluno1, K F Faull.   

Abstract

We report the ability of 3-amino-L-tyrosine to act as a fully reversible competitive inhibitor of mushroom tyrosinase. The inhibition is linked to the ortho-aminophenol structure, and a copper bridging mechanism in the active site is proposed.

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Year:  1988        PMID： 3141207     DOI： 10.1007/bf01941189

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  7 in total

1.  Structures and functions of the phenolase complex.

Authors:  H S MASON
Journal:  Nature       Date:  1956-01-14       Impact factor: 49.962

2.  Optimization of hydroxylation of tyrosine and tyrosine-containing peptides by mushroom tyrosinase.

Authors:  K Marumo; J H Waite
Journal:  Biochim Biophys Acta       Date:  1986-07-25

3.  Copper ion binding and enzyme inhibitory properties of the antithyroid drug methimazole.

Authors:  D P Hanlon; S Shuman
Journal:  Experientia       Date:  1975-09-15

4.  Molecular basis of substrate and inhibitory specificity of tyrosinase: phenolic compounds.

Authors:  S Passi; M Nazzaro-Porro
Journal:  Br J Dermatol       Date:  1981-06       Impact factor: 9.302

5.  Inhibition of melanoma tyrosinase by fusaric acid.

Authors:  T Nagatsu; I Sudo; T Okada; H Umezawa; T Takeuchi
Journal:  Experientia       Date:  1972-06-15

6.  Chorismate mutase-prephenate dehydrogenase from Escherichia coli: cooperative effects and inhibition by L-tyrosine.

Authors:  R I Christopherson
Journal:  Arch Biochem Biophys       Date:  1985-08-01       Impact factor: 4.013

7.  Extended X-ray absorption fine structure study of the coupled binuclear copper active site of tyrosinase from Neurospora crassa.

Authors:  G L Woolery; L Powers; M Winkler; E I Solomon; K Lerch; T G Spiro
Journal:  Biochim Biophys Acta       Date:  1984-07-31
  7 in total
  3 in total

1.  Study of the docking of competitive inhibitors at a model of tyrosinase active site: insights from joint broken-symmetry/Spin-Flip DFT computations and ELF topological analysis.

Authors:  A de la Lande; J Maddaluno; O Parisel; T A Darden; J-P Piquemal
Journal:  Interdiscip Sci       Date:  2010-03       Impact factor: 2.233

2.  Comments on the nature of the bonding in oxygenated dinuclear copper enzyme models.

Authors:  Jean-Philip Piquemal; Julien Pilmé
Journal:  J Mol Struct       Date:  2006-05-30       Impact factor: 3.196

3.  Multifunctional Tyrosinase Inhibitor Peptides with Copper Chelating, UV-Absorption and Antioxidant Activities: Kinetic and Docking Studies.

Authors:  Pei-Gee Yap; Chee-Yuen Gan
Journal:  Foods       Date:  2021-03-22
  3 in total

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