Literature DB >> 8090074

In situ hybridization of antisense mRNA oligonucleotides for AMPA, NMDA and metabotropic glutamate receptor subtypes in the rat suprachiasmatic nucleus at different phases of the circadian cycle.

R L Gannon1, M A Rea.   

Abstract

Eleven oligonucleotides directed against mRNA for AMPA, NMDA and metabotropic glutamate receptor subtypes were hybridized to rat coronal brain sections containing the suprachiasmatic nucleus (SCN). These oligonucleotides were hybridized to tissue samples collected at midday and midnight phases of the circadian cycle. Glutamate receptor mRNA for the AMPA subunits GluR1, GluR2 and GluR4, and the NMDA receptor subtype NMDAR1, were heavily expressed in the SCN and surrounding areas. The mRNA for the metabotropic glutamate subunit mGluR1 was only lightly expressed in the SCN. In contrast, mRNA for NMDAR2A, NMDAR2B, NMDAR2C and GluR3 was not detected in the SCN. The mRNA found to be expressed in the rat SCN was similar in samples collected at midday and midnight, suggesting no circadian variation in endogenous SCN glutamate receptors at these two times of the light-dark cycle.

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Year:  1994        PMID： 8090074     DOI： 10.1016/0169-328x(94)90244-5

Source DB:  PubMed          Journal:  Brain Res Mol Brain Res        ISSN： 0169-328X


  17 in total

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5.  Glutamate-Dependent BMAL1 Regulation in Cultured Bergmann Glia Cells.

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6.  Synaptic input from the retina to the suprachiasmatic nucleus changes with the light-dark cycle in the Syrian hamster.

Authors:  L N Cui; R E Dyball
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7.  Excitatory mechanisms in the suprachiasmatic nucleus: the role of AMPA/KA glutamate receptors.

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8.  Role for the NR2B subunit of the N-methyl-D-aspartate receptor in mediating light input to the circadian system.

Authors:  L M Wang; A Schroeder; D Loh; D Smith; K Lin; J H Han; S Michel; D L Hummer; J C Ehlen; H E Albers; C S Colwell
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9.  Activation of AMPA receptors in the suprachiasmatic nucleus phase-shifts the mouse circadian clock in vivo and in vitro.

Authors:  Yasutaka Mizoro; Yoshiaki Yamaguchi; Rena Kitazawa; Hiroyuki Yamada; Masahiro Matsuo; Jean-Michel Fustin; Masao Doi; Hitoshi Okamura
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10.  Pituitary adenylate cyclase-activating polypeptide and melatonin in the suprachiasmatic nucleus: effects on the calcium signal transduction cascade.

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Journal:  J Neurosci       Date:  1999-01-01       Impact factor: 6.167
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