OBJECTIVE: To determine the association between the e4 allele of apolipoprotein E and Alzheimer's disease in a randomly selected population sample. DESIGN: Cross sectional population based study. SUBJECTS: 980 people aged 69 to 78 (349 men, 631 women). SETTING: Population of Kuopio, eastern Finland. MAIN OUTCOME MEASURES: Presence of e4 allele and diagnosis of Alzheimer's disease by detailed neurological and neurophysiological evaluation. RESULTS: 46 (4.7%) subjects were classified as having probable or possible Alzheimer's disease. The frequency of the apolipoprotein E e4 allele was 0.359 in patients with Alzheimer's disease and 0.165 subjects without dementia (P < 0.0001). The prevalence of Alzheimer's disease was 2.9% in subjects with no e4 alleles, 7.6% in subjects with one e4 allele, and 21.4% in subjects with two e4 alleles of apolipoprotein E. CONCLUSIONS: Allele e4 of apolipoprotein is associated with Alzheimer's disease in a dose-response fashion in a randomly selected elderly population.
OBJECTIVE: To determine the association between the e4 allele of apolipoprotein E and Alzheimer's disease in a randomly selected population sample. DESIGN: Cross sectional population based study. SUBJECTS: 980 people aged 69 to 78 (349 men, 631 women). SETTING: Population of Kuopio, eastern Finland. MAIN OUTCOME MEASURES: Presence of e4 allele and diagnosis of Alzheimer's disease by detailed neurological and neurophysiological evaluation. RESULTS: 46 (4.7%) subjects were classified as having probable or possible Alzheimer's disease. The frequency of the apolipoprotein E e4 allele was 0.359 in patients with Alzheimer's disease and 0.165 subjects without dementia (P < 0.0001). The prevalence of Alzheimer's disease was 2.9% in subjects with no e4 alleles, 7.6% in subjects with one e4 allele, and 21.4% in subjects with two e4 alleles of apolipoprotein E. CONCLUSIONS: Allele e4 of apolipoprotein is associated with Alzheimer's disease in a dose-response fashion in a randomly selected elderly population.
Authors: H Bickeböller; D Campion; A Brice; P Amouyel; D Hannequin; O Didierjean; C Penet; C Martin; J Pérez-Tur; A Michon; B Dubois; F Ledoze; C Thomas-Anterion; F Pasquier; M Puel; J F Demonet; O Moreaud; M C Babron; D Meulien; D Guez; M C Chartier-Harlin; T Frebourg; Y Agid; M Martinez; F Clerget-Darpoux Journal: Am J Hum Genet Date: 1997-02 Impact factor: 11.025
Authors: M X Tang; G Maestre; W Y Tsai; X H Liu; L Feng; W Y Chung; M Chun; P Schofield; Y Stern; B Tycko; R Mayeux Journal: Am J Hum Genet Date: 1996-03 Impact factor: 11.025
Authors: M Lehtovirta; H Soininen; M P Laakso; K Partanen; S Helisalmi; A Mannermaa; M Ryynänen; J Kuikka; P Hartikainen; P J Riekkinen Journal: J Neurol Neurosurg Psychiatry Date: 1996-06 Impact factor: 10.154
Authors: Maria Bjerke; Erik Portelius; Lennart Minthon; Anders Wallin; Henrik Anckarsäter; Rolf Anckarsäter; Niels Andreasen; Henrik Zetterberg; Ulf Andreasson; Kaj Blennow Journal: Int J Alzheimers Dis Date: 2010-07-15
Authors: H A D Keage; F E Matthews; A Yip; L Gao; C McCracken; I G McKeith; D C Rubinsztein; C Brayne Journal: Age Ageing Date: 2009-11-24 Impact factor: 10.668