Literature DB >> 3082422

Confidence intervals rather than P values: estimation rather than hypothesis testing.

M J Gardner, D G Altman.   

Abstract

Overemphasis on hypothesis testing--and the use of P values to dichotomise significant or non-significant results--has detracted from more useful approaches to interpreting study results, such as estimation and confidence intervals. In medical studies investigators are usually interested in determining the size of difference of a measured outcome between groups, rather than a simple indication of whether or not it is statistically significant. Confidence intervals present a range of values, on the basis of the sample data, in which the population value for such a difference may lie. Some methods of calculating confidence intervals for means and differences between means are given, with similar information for proportions. The paper also gives suggestions for graphical display. Confidence intervals, if appropriate to the type of study, should be used for major findings in both the main text of a paper and its abstract.

Mesh:

Year:  1986        PMID: 3082422      PMCID: PMC1339793          DOI: 10.1136/bmj.292.6522.746

Source DB:  PubMed          Journal:  Br Med J (Clin Res Ed)        ISSN: 0267-0623


  9 in total

1.  Clinical biostatistics. XXXVII. Demeaned errors, confidence games, nonplussed minuses, inefficient coefficients, and other statistical disruptions of scientific communication.

Authors:  A R Feinstein
Journal:  Clin Pharmacol Ther       Date:  1976-11       Impact factor: 6.875

2.  A show of confidence.

Authors:  K J Rothman
Journal:  N Engl J Med       Date:  1978-12-14       Impact factor: 91.245

3.  Statistical guidelines for contributors to medical journals.

Authors:  D G Altman; S M Gore; M J Gardner; S J Pocock
Journal:  Br Med J (Clin Res Ed)       Date:  1983-05-07

4.  Letter: Understanding and presenting variation.

Authors:  M J Gardner
Journal:  Lancet       Date:  1975-01-25       Impact factor: 79.321

5.  Statistical ritual in clinical journals: is there a cure?--I.

Authors:  D Mainland
Journal:  Br Med J (Clin Res Ed)       Date:  1984-03-17

6.  Statistics and ethics in medical research. VI--Presentation of results.

Authors:  D G Altman
Journal:  Br Med J       Date:  1980-12-06

7.  Simultaneous inference in epidemiological studies.

Authors:  D R Jones; L Rushton
Journal:  Int J Epidemiol       Date:  1982-09       Impact factor: 7.196

8.  Statistics in medical journals.

Authors:  D G Altman
Journal:  Stat Med       Date:  1982 Jan-Mar       Impact factor: 2.373

9.  Diabetes and cardiovascular risk factors: the Framingham study.

Authors:  W B Kannel; D L McGee
Journal:  Circulation       Date:  1979-01       Impact factor: 29.690

  9 in total
  360 in total

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Review 3.  Biological interpretation of relative risk.

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Journal:  Drug Saf       Date:  1999-08       Impact factor: 5.606

4.  Reporting of numerical and statistical differences in abstracts: improving but not optimal.

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Journal:  J Gen Intern Med       Date:  2002-03       Impact factor: 5.128

5.  Persistent alterations in dendrites, spines, and dynorphinergic synapses in the nucleus accumbens shell of rats with neuroleptic-induced dyskinesias.

Authors:  G E Meredith; I E De Souza; T M Hyde; G Tipper; M L Wong; M F Egan
Journal:  J Neurosci       Date:  2000-10-15       Impact factor: 6.167

6.  Detection of intra- and cross-cultural non-equivalence by simple methods in cross-cultural research: evidence from a study of eating attitudes in Nigeria and Britain.

Authors:  C Evans; B Dolan; A Toriola
Journal:  Eat Weight Disord       Date:  1997-06       Impact factor: 4.652

7.  Effects of alpha-adrenoceptor and of combined sympathetic and parasympathetic blockade on cardiac performance and vascular resistance.

Authors:  H Kelbaek; H Frandsen; J Hilsted; N J Christensen; S L Nielsen
Journal:  Br J Clin Pharmacol       Date:  1992-05       Impact factor: 4.335

8.  Lack of pharmacokinetic interactions between moxonidine and digoxin.

Authors:  G Pabst; H J Weimann; W Weber
Journal:  Clin Pharmacokinet       Date:  1992-12       Impact factor: 6.447

9.  Early stage autoinduction of carbamazepine metabolism in humans.

Authors:  I Bernus; R G Dickinson; W D Hooper; M J Eadie
Journal:  Eur J Clin Pharmacol       Date:  1994       Impact factor: 2.953

10.  Morphometric comparison of synovium from patients with osteoarthritis and rheumatoid arthritis.

Authors:  T D Kennedy; C Plater-Zyberk; T A Partridge; D F Woodrow; R N Maini
Journal:  J Clin Pathol       Date:  1988-08       Impact factor: 3.411

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