Literature DB >> 8086594

Probability of gene identity by descent: computation and applications.

A S Whittemore1, J Halpern.   

Abstract

Two genes at a given locus are identical by descent (IBD) if both have been inherited from a common ancestor. We present an algorithm for computing the probabilities of all IBD relationships among the genes of pedigree members. We show how to use these probabilities to calculate the probability of any combination of genotypes or phenotypes for the pedigree members. Applications to linkage analysis and genetic counseling are illustrated with examples. The algorithm also can be used to calculate the generalized kinship coefficients proposed by others.

Mesh：

Year:  1994        PMID： 8086594

Source DB:  PubMed          Journal:  Biometrics        ISSN： 0006-341X            Impact factor:   2.571


  18 in total

1.  Direct power comparisons between simple LOD scores and NPL scores for linkage analysis in complex diseases.

Authors:  P C Abreu; D A Greenberg; S E Hodge
Journal:  Am J Hum Genet       Date:  1999-09       Impact factor: 11.025

2.  On a randomization procedure in linkage analysis.

Authors:  H Zhao; K R Merikangas; K K Kidd
Journal:  Am J Hum Genet       Date:  1999-11       Impact factor: 11.025

3.  An additive genetic gamma frailty model for linkage analysis of diseases with variable age of onset using nuclear families.

Authors:  Hongzhe Li
Journal:  Lifetime Data Anal       Date:  2002-12       Impact factor: 1.588

Review 4.  Linkage analysis in the next-generation sequencing era.

Authors:  Joan E Bailey-Wilson; Alexander F Wilson
Journal:  Hum Hered       Date:  2011-12-23       Impact factor: 0.444

Review 5.  Genomic similarity and kernel methods I: advancements by building on mathematical and statistical foundations.

Authors:  Daniel J Schaid
Journal:  Hum Hered       Date:  2010-07-03       Impact factor: 0.444

6.  A new locus on 3p23-p25 for an autosomal-dominant limb-girdle muscular dystrophy, LGMD1H.

Authors:  Luigi Bisceglia; Stefano Zoccolella; Alessandra Torraco; Maria Rosaria Piemontese; Rosa Dell'Aglio; Angela Amati; Patrizia De Bonis; Lucia Artuso; Massimiliano Copetti; Filippo Maria Santorelli; Luigi Serlenga; Leopoldo Zelante; Enrico Bertini; Vittoria Petruzzella
Journal:  Eur J Hum Genet       Date:  2010-01-13       Impact factor: 4.246

7.  Nonparametric simulation-based statistics for detecting linkage in general pedigrees.

Authors:  S Davis; M Schroeder; L R Goldin; D E Weeks
Journal:  Am J Hum Genet       Date:  1996-04       Impact factor: 11.025

8.  Unifying ideas for non-parametric linkage analysis.

Authors:  Aaron G Day-Williams; John Blangero; Thomas D Dyer; Kenneth Lange; Eric M Sobel
Journal:  Hum Hered       Date:  2011-08-03       Impact factor: 0.444

9.  Multipoint quantitative-trait linkage analysis in general pedigrees.

Authors:  L Almasy; J Blangero
Journal:  Am J Hum Genet       Date:  1998-05       Impact factor: 11.025

10.  Genetic predisposition to self-curing infection with the protozoan Leishmania chagasi: a genomewide scan.

Authors:  Selma M B Jeronimo; Priya Duggal; Nicholas A Ettinger; Eliana T Nascimento; Gloria R Monteiro; Angela P Cabral; Nubia N Pontes; Henio G Lacerda; Paula V Queiroz; Carlos E M Gomes; Richard D Pearson; Jenefer M Blackwell; Terri H Beaty; Mary E Wilson
Journal:  J Infect Dis       Date:  2007-09-13       Impact factor: 5.226
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