Literature DB >> 808612

Aromatic esters of 5-O-desosaminylerythronolide A oxime.

R A LeMahieu, M Carson, R W Kierstead, S Pestka.   

Abstract

Several substituted aromatic esters of the C-3 hydroxyl of 5-O-desosaminylerythronolide A oxime were prepared. Ribosomal binding studies showed that meta substituents on the aromatic ring gave the most active analogs. The esters described were all inactive in vivo at the maximum level tested.

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Year:  1975        PMID: 808612     DOI: 10.1021/jm00242a020

Source DB:  PubMed          Journal:  J Med Chem        ISSN: 0022-2623            Impact factor:   7.446


  1 in total

1.  Fluorescent assay for estimating the binding of erythromycin derivatives to ribosomes.

Authors:  P Brandt-Rauf; R Vince; R LeMahieu; S Pestka
Journal:  Antimicrob Agents Chemother       Date:  1978-07       Impact factor: 5.191

  1 in total

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