Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Evaluation of a morpholinothiolporphyrin for use in photodynamic therapy.

Literature DB >> 8080721

Evaluation of a morpholinothiolporphyrin for use in photodynamic therapy.

K W Woodburn¹, J S Hill, S Stylli, A H Kaye, J A Reiss, D R Phillips.

Abstract

The photonecrotic effectiveness of a morpholinothiolporphyrin derived from haematoporphyrin was measured in an animal model of cerebral glioma. The dose administered was 20 mg kg-1 and the laser dose varied from 0 to 200 J cm-2. The tumour necrosis was at least as good as that of HpD, and this therapeutic response may be attributed to the targeting of specific 'photopotent' subcellular sites.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1994 PMID： 8080721 PMCID： PMC2033371 DOI： 10.1038/bjc.1994.316

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

13 in total

1. Role of lysosomes and of cell membranes in photosensitization.

Authors: A C Allison; I A Magnus; M R Young
Journal: Nature Date: 1966-02-26 Impact factor: 49.962

2. Studies on the structure of porphyrins contained in Photofrin II.

Authors: T J Dougherty
Journal: Photochem Photobiol Date: 1987-11 Impact factor: 3.421

Review 3. Local tissue hyperacidification and lysosomes.

Authors: M von Ardenne; W Krüger
Journal: Front Biol Date: 1979

4. Selective uptake of hematoporphyrin derivative into human cerebral glioma.

Authors: J S Hill; A H Kaye; W H Sawyer; G Morstyn; P D Megison; S S Stylli
Journal: Neurosurgery Date: 1990-02 Impact factor: 4.654

5. Determination of [3H]- and [14C]hematoporphyrin derivative distribution in malignant and normal tissue.

Authors: C J Gomer; T J Dougherty
Journal: Cancer Res Date: 1979-01 Impact factor: 12.701

Review 6. Photoradiation therapy and its potential in the management of neurological tumors.

Authors: A H Kaye; G Morstyn; M L Apuzzo
Journal: J Neurosurg Date: 1988-07 Impact factor: 5.115

7. Uptake and retention of hematoporphyrin derivative in an in vivo/in vitro model of cerebral glioma.

Authors: A H Kaye; G Morstyn; R G Ashcroft
Journal: Neurosurgery Date: 1985-12 Impact factor: 4.654

8. Photosensitizing efficiencies, tumor- and cellular uptake of different photosensitizing drugs relevant for photodynamic therapy of cancer.

Authors: J Moan; Q Peng; J F Evensen; K Berg; A Western; C Rimington
Journal: Photochem Photobiol Date: 1987-11 Impact factor: 3.421

Evaluation of a morpholinothiolporphyrin for use in photodynamic therapy.

1. Role of lysosomes and of cell membranes in photosensitization.

2. Studies on the structure of porphyrins contained in Photofrin II.

Review 3. Local tissue hyperacidification and lysosomes.

4. Selective uptake of hematoporphyrin derivative into human cerebral glioma.

5. Determination of [3H]- and [14C]hematoporphyrin derivative distribution in malignant and normal tissue.

Review 6. Photoradiation therapy and its potential in the management of neurological tumors.

7. Uptake and retention of hematoporphyrin derivative in an in vivo/in vitro model of cerebral glioma.

8. Photosensitizing efficiencies, tumor- and cellular uptake of different photosensitizing drugs relevant for photodynamic therapy of cancer.

9. Photoradiation therapy causing selective tumor kill in a rat glioma model.

10. The mechanism of photodynamic inactivation of human cells in vitro in the presence of haematoporphyrin.

1. Evidence for ectopic aerobic ATP production on C6 glioma cell plasma membrane.

2. A theoretical formalism for aggregation of peroxidized lipids and plasma membrane stability during photolysis.