Literature DB >> 8076949

Chromosomal localization of the human histone H2A.X gene to 11q23.2-q23.3 by fluorescence in situ hybridization.

V S Ivanova1, D Zimonjic, N Popescu, W M Bonner.   

Abstract

The human histone H2A.X gene is unusual in that its transcripts are alternatively processed to yield two species, one a 0.6-kb replication-linked histone mRNA and the other a 1.6-kb polyadenylated mRNA. The H2A.X gene has been localized by fluorescence in situ hybridization to chromosome 11q23.2-q23.3, away from the known clusters of human histone genes on chromosomes 1, 6, and 12. Assignment to chromosome 11 was substantiated by analysis of human-hamster somatic cell hybrid lines. As this work was being completed, an 89-bps sequence overlap was found between the downstream regions of the H2A.X gene and the recently sequenced hydroxymethylbilane (HMB)-synthase gene. The H2A.X and HMB-synthase genes have an unusual arrangement, being transcribed towards each other with their polyadenylation sites 330 bp apart. In addition the HMB-synthase gene contains constitutive and erythroid specific promoters. K562, an erythroid cell line, was found to contain a high concentration of the 1.6-kb polyadenylated H2A.X mRNA.

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Year:  1994        PMID： 8076949     DOI： 10.1007/bf00208289

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  19 in total

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Journal:  Exp Cell Res       Date:  1991-07       Impact factor: 3.905

Review 2.  Multiple recurrent genomic rearrangements and fragile sites in human cancer.

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Journal:  Somat Cell Mol Genet       Date:  1987-07

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4.  Fluorescence in situ hybridization with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4.

Authors:  D Pinkel; J Landegent; C Collins; J Fuscoe; R Segraves; J Lucas; J Gray
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

5.  The relative expression of human histone H2A genes is similar in different types of proliferating cells.

Authors:  C Mannironi; A Orr; C Hatch; D Pilch; V Ivanova; W Bonner
Journal:  DNA Cell Biol       Date:  1994-02       Impact factor: 3.311

6.  H2A.X. a histone isoprotein with a conserved C-terminal sequence, is encoded by a novel mRNA with both DNA replication type and polyA 3' processing signals.

Authors:  C Mannironi; W M Bonner; C L Hatch
Journal:  Nucleic Acids Res       Date:  1989-11-25       Impact factor: 16.971

7.  Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias.

Authors:  D C Tkachuk; S Kohler; M L Cleary
Journal:  Cell       Date:  1992-11-13       Impact factor: 41.582

8.  A physical linkage group in human chromosome band 11q23 covering a region implicated in leukocyte neoplasia.

Authors:  A Tunnacliffe; R S McGuire
Journal:  Genomics       Date:  1990-11       Impact factor: 5.736

9.  Histone H2A.X gene transcription is regulated differently than transcription of other replication-linked histone genes.

Authors:  W M Bonner; C Mannironi; A Orr; D R Pilch; C L Hatch
Journal:  Mol Cell Biol       Date:  1993-02       Impact factor: 4.272

10.  Human histone genes map to multiple chromosomes.

Authors:  P Tripputi; B S Emanuel; C M Croce; L G Green; G S Stein; J L Stein
Journal:  Proc Natl Acad Sci U S A       Date:  1986-05       Impact factor: 11.205
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  6 in total

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2.  Mapping of a human rRNA gene in the YAC contig surrounding the SMA candidate gene.

Authors:  J Huschenbett; A Gasch; A Katzer; M Affeldt; A Speer
Journal:  Hum Genet       Date:  1995-09       Impact factor: 4.132

Review 3.  Variants of core histones and their roles in cell fate decisions, development and cancer.

Authors:  Marcus Buschbeck; Sandra B Hake
Journal:  Nat Rev Mol Cell Biol       Date:  2017-02-01       Impact factor: 94.444

Review 4.  Cytometric assessment of DNA damage in relation to cell cycle phase and apoptosis.

Authors:  Xuan Huang; H Dorota Halicka; Frank Traganos; Toshiki Tanaka; Akira Kurose; Zbigniew Darzynkiewicz
Journal:  Cell Prolif       Date:  2005-08       Impact factor: 6.831

5.  A solitary human H3 histone gene on chromosome 1.

Authors:  W Albig; J Ebentheuer; G Klobeck; J Kunz; D Doenecke
Journal:  Hum Genet       Date:  1996-04       Impact factor: 4.132

6.  Genetic variants in the H2AFX promoter region are associated with risk of sporadic breast cancer in non-Hispanic white women aged <or=55 years.

Authors:  Jiachun Lu; Qingyi Wei; Melissa L Bondy; Abenaa M Brewster; Therese B Bevers; Tse-Kuan Yu; Thomas A Buchholz; Funda Meric-Bernstam; Kelly K Hunt; S Eva Singletary; Li-E Wang
Journal:  Breast Cancer Res Treat       Date:  2007-09-13       Impact factor: 4.872
  6 in total

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