UNLABELLED: A potential limitation of rhenium-186-1,1-hydroxyethylidene diphosphonate (186Re-HEDP) therapy in patients with painful bone metastases is thrombocytopenia. Given the palliative character of this therapy, it is essential to be able to predict the degree of thrombocytopenia before therapy. METHODS: Thus far, 39 prostatic cancer patients with multiple painful bone metastases were treated. Twenty-one patients underwent the therapy twice, resulting in 60 therapies. From the pre-therapy 99mTc-HDP scintigram, the bone scan index (BSI) was determined as an index of the extent of bone involvement. RESULTS: The administered activity ranged from 1104 to 3479 MBq 186Re-HEDP. The platelet count was lowest 4 wk following therapy. From this value and the pretreatment level, the percentage decrease in the platelet count was determined (47% +/- 19%, range 14%-89%). The BSI ranged from 8 to 93. Regression analysis showed a functional relation (R = 0.78; p < 0.001) of the percentage of platelet decrease with BSI and administered activity normalized to standard body surface area. CONCLUSION: Using this relation, it is possible to predict thrombocytopenia by pretreatment bone scintigraphy and to adjust the dosage to each patient to avoid unacceptable toxicity.
UNLABELLED: A potential limitation of rhenium-186-1,1-hydroxyethylidene diphosphonate (186Re-HEDP) therapy in patients with painful bone metastases is thrombocytopenia. Given the palliative character of this therapy, it is essential to be able to predict the degree of thrombocytopenia before therapy. METHODS: Thus far, 39 prostatic cancerpatients with multiple painful bone metastases were treated. Twenty-one patients underwent the therapy twice, resulting in 60 therapies. From the pre-therapy 99mTc-HDP scintigram, the bone scan index (BSI) was determined as an index of the extent of bone involvement. RESULTS: The administered activity ranged from 1104 to 3479 MBq 186Re-HEDP. The platelet count was lowest 4 wk following therapy. From this value and the pretreatment level, the percentage decrease in the platelet count was determined (47% +/- 19%, range 14%-89%). The BSI ranged from 8 to 93. Regression analysis showed a functional relation (R = 0.78; p < 0.001) of the percentage of platelet decrease with BSI and administered activity normalized to standard body surface area. CONCLUSION: Using this relation, it is possible to predict thrombocytopenia by pretreatment bone scintigraphy and to adjust the dosage to each patient to avoid unacceptable toxicity.
Authors: J M O'Sullivan; A R Norman; V R McCready; G Flux; F M Buffa; B Johnson; J Coffey; G Cook; J Treleaven; A Horwich; R A Huddart; C C Parker; D P Dearnaley Journal: Eur J Nucl Med Mol Imaging Date: 2006-03-30 Impact factor: 9.236
Authors: Joyce M van Dodewaard-de Jong; John M H de Klerk; Haiko J Bloemendal; Bart P J van Bezooijen; Marie J de Haas; Richard H Wilson; Joe M O'Sullivan Journal: Eur J Nucl Med Mol Imaging Date: 2011-07-27 Impact factor: 9.236
Authors: Eduardo Savio; Javier Gaudiano; Ana M Robles; Henia Balter; Andrea Paolino; Andrea López; Juan C Hermida; Eugenia De Marco; Graciela Martinez; Eduardo Osinaga; Furn F Knapp Journal: BMC Nucl Med Date: 2001
Authors: Ana M Denis-Bacelar; Sarah J Chittenden; David P Dearnaley; Antigoni Divoli; Joe M O'Sullivan; V Ralph McCready; Bernadette Johnson; Yong Du; Glenn D Flux Journal: Eur J Nucl Med Mol Imaging Date: 2016-10-21 Impact factor: 9.236
Authors: Ajit S Shinto; Madhava B Mallia; Mythili Kameswaran; K K Kamaleshwaran; Jephy Joseph; E R Radhakrishnan; Indira V Upadhyay; R Subramaniam; Madhu Sairam; Sharmila Banerjee; Ashutosh Dash Journal: World J Nucl Med Date: 2018 Oct-Dec
Authors: J M O'Sullivan; V R McCready; G Flux; A R Norman; F M Buffa; S Chittenden; M Guy; K Pomeroy; G Cook; J Gadd; J Treleaven; A Al-Deen; A Horwich; R A Huddart; D P Dearnaley Journal: Br J Cancer Date: 2002-06-05 Impact factor: 7.640