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Literature DB >> 8067899

Acetylsalicylic acid--inducer of cytochrome P-450 2E1?

Abstract

Pretreatment of rats with acetylsalicylic acid or sodium salicylate stimulates the metabolism of dichloromethane to carbon monoxide as measured by the carboxyhemoglobin level in blood. Simultaneous administration of dichloromethane and acetylsalicylic acid or sodium salicylate, respectively, was accompanied by reduced carboxyhemoglobin formation. In liver microsomes of rats pretreated with acetylsalicylic acid the p-nitrophenol hydroxylase activity was increased. It is concluded that (i) cytochrome P-450 2E1 is involved in the metabolic conversion of both dichloromethane and salicylic acid, and (ii) salicylic acid may be an inducer of cytochrome P-450 2E1.

Entities: Chemical Gene Species

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Year: 1994 PMID： 8067899 DOI： 10.1007/s002040050066

Source DB: PubMed Journal: Arch Toxicol ISSN： 0340-5761 Impact factor: 5.153

20 in total

1. THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.

Authors: T OMURA; R SATO
Journal: J Biol Chem Date: 1964-07 Impact factor: 5.157

2. The effect of combined exposures to ethanol and xylene on rat hepatic microsomal monooxygenase activities.

Authors: J M Wiśniewska-Knypl; T Wrońska-Nofer; J Jajte; U Jedlińska
Journal: Alcohol Date: 1989 Sep-Oct Impact factor: 2.405

3. Dichloromethane metabolism to carbon monoxide can be induced by isoniazid, acetone and fasting.

Authors: D Pankow; P Hoffmann
Journal: Arch Toxicol Suppl Date: 1989

4. 2,3-Dihydroxybenzoic acid is a product of human aspirin metabolism.

Authors: M Grootveld; B Halliwell
Journal: Biochem Pharmacol Date: 1988-01-15 Impact factor: 5.858

5. Toluene metabolism in isolated rat hepatocytes: effects of in vivo pretreatment with acetone and phenobarbital.

Authors: A Smith-Kielland; A Ripel
Journal: Arch Toxicol Date: 1993 Impact factor: 5.153

6. Model representation of salicylate pharmacokinetics using unbound plasma salicylate concentrations and metabolite urinary excretion rates following a single oral dose.

Authors: J Shen; S Wanwimolruk; R D Purves; E G McQueen; M S Roberts
Journal: J Pharmacokinet Biopharm Date: 1991-10

1. Aspirin-triggered lipoxins (15-epi-LX) are generated by the human lung adenocarcinoma cell line (A549)-neutrophil interactions and are potent inhibitors of cell proliferation.

Authors: J Clària; M H Lee; C N Serhan
Journal: Mol Med Date: 1996-09 Impact factor: 6.354

2. Lipophilic versus hydrophilic beta(1) blockers and the cardiac sympatho-vagal balance during stress and daily activity in patients after acute myocardial infarction.

Authors: A Kardos; V Long; J Bryant; J Singh; P Sleight; B Casadei
Journal: Heart Date: 1998-02 Impact factor: 5.994

2 in total

Acetylsalicylic acid--inducer of cytochrome P-450 2E1?

1. THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.

2. The effect of combined exposures to ethanol and xylene on rat hepatic microsomal monooxygenase activities.

3. Dichloromethane metabolism to carbon monoxide can be induced by isoniazid, acetone and fasting.

4. 2,3-Dihydroxybenzoic acid is a product of human aspirin metabolism.

5. Toluene metabolism in isolated rat hepatocytes: effects of in vivo pretreatment with acetone and phenobarbital.

6. Model representation of salicylate pharmacokinetics using unbound plasma salicylate concentrations and metabolite urinary excretion rates following a single oral dose.

7. Influence of P-4502E1 induction on benzene metabolism in rat hepatocytes and on biliary metabolite excretion.

8. Pyridine induction of cytochrome P-450 in the rat: role of P-450j (alcohol-inducible form) in pyridine N-oxidation.

9. Hydroxylation of p-nitrophenol by rabbit ethanol-inducible cytochrome P-450 isozyme 3a.

10. Metabolism of aspirin after therapeutic and toxic doses.

1. Aspirin-triggered lipoxins (15-epi-LX) are generated by the human lung adenocarcinoma cell line (A549)-neutrophil interactions and are potent inhibitors of cell proliferation.

2. Lipophilic versus hydrophilic beta(1) blockers and the cardiac sympatho-vagal balance during stress and daily activity in patients after acute myocardial infarction.