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Literature DB >> 3342084

2,3-Dihydroxybenzoic acid is a product of human aspirin metabolism.

Abstract

2,3-Dihydroxybenzoic acid is present in blood plasma and urine of healthy human volunteers after aspirin ingestion. Its identity has been confirmed by mass spectrometry and by electrochemical analysis. Methods for its identification and measurement are described. The concentration of 2,3-dihydroxybenzoic acid is much lower than that of 2,5-dihydroxybenzoic acid, salicylic acid or salicyluric acid.

Entities: Chemical Species

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Substances：

Year: 1988 PMID： 3342084 DOI： 10.1016/0006-2952(88)90729-0

Source DB: PubMed Journal: Biochem Pharmacol ISSN： 0006-2952 Impact factor: 5.858

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Cited

15 in total

1. Aromatic hydroxylation of salicylic acid and aspirin by human cytochromes P450.

Authors: Mirza Bojić; Carl A Sedgeman; Leslie D Nagy; F Peter Guengerich
Journal: Eur J Pharm Sci Date: 2015-03-31 Impact factor: 4.384

2. 2,3-dihydroxybenzoic acid-containing nanofiber wound dressings inhibit biofilm formation by Pseudomonas aeruginosa.

Authors: Jayesh J Ahire; Leon M T Dicks
Journal: Antimicrob Agents Chemother Date: 2014-01-21 Impact factor: 5.191

3. Hydroxylation of salicylate by microsomal fractions and cytochrome P-450. Lack of production of 2,3-dihydroxybenzoate unless hydroxyl radical formation is permitted.

Authors: M Ingelman-Sundberg; H Kaur; Y Terelius; J O Persson; B Halliwell
Journal: Biochem J Date: 1991-06-15 Impact factor: 3.857

2,3-Dihydroxybenzoic acid is a product of human aspirin metabolism.

1. Aromatic hydroxylation of salicylic acid and aspirin by human cytochromes P450.

2. 2,3-dihydroxybenzoic acid-containing nanofiber wound dressings inhibit biofilm formation by Pseudomonas aeruginosa.

3. Hydroxylation of salicylate by microsomal fractions and cytochrome P-450. Lack of production of 2,3-dihydroxybenzoate unless hydroxyl radical formation is permitted.

4. Aspirin metabolites are GPR35 agonists.

5. The identification of salicylates as normal constituents of serum: a link between diet and health?

6. Reaction of dipyridamole with the hydroxyl radical.

7. Is aspirin a prodrug for antioxidant and cytokine-modulating oxymetabolites?

8. Acetylsalicylic acid--inducer of cytochrome P-450 2E1?

9. Assessment of antioxidant effect of 2,5-dihydroxybenzoic acid and vitamin a in brains of rats with induced hyperoxia.

Review 10. Hydroxybenzoic acid isomers and the cardiovascular system.