Literature DB >> 8067764

Transferability and genetic relatedness of high-level gentamicin resistance among enterococci.

D F Sahm1, M S Gilmore.   

Abstract

Gentamicin resistance in six enterococcal species was investigated. Transfer of resistance was observed for the donors E. faecium UC 79, E. avium CC 54, and E. gallinarum B 51, but not for E. raffinosus UC 78 or E. casseliflavus UC 73. Except for E. casseliflavus UC 73, homology was observed between the E. faecalis aac6'-aph2" gene and DNA from other species. Whereas 2.6-kb HindIII fragments encoded resistance in E. faecalis UC 244, its transconjugant, and E. raffinosus UC 78, 3.4-kb fragments encoded resistance in E. faecium UC 79, E. gallinarum B 51, and their transconjugants. A 3.4-kb fragment encoded resistance in E. avium CC 54, but 2.6-kb fragments encoded resistance in the transconjugants. Although many similarities were found among the strains, the heterogeneity in gentamicin resistance exhibited by some isolates indicates diversity among these determinants.

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Year:  1994        PMID： 8067764      PMCID： PMC188178          DOI： 10.1128/AAC.38.5.1194

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

1.  High-level, plasmid-borne resistance to gentamicin in Streptococcus faecalis subsp. zymogenes.

Authors:  T Horodniceanu; L Bougueleret; N El-Solh; G Bieth; F Delbos
Journal:  Antimicrob Agents Chemother       Date:  1979-11       Impact factor: 5.191

2.  Identical genes confer high-level resistance to gentamicin upon Enterococcus faecalis, Enterococcus faecium, and Streptococcus agalactiae.

Authors:  A Kaufhold; A Podbielski; T Horaud; P Ferrieri
Journal:  Antimicrob Agents Chemother       Date:  1992-06       Impact factor: 5.191

3.  Nucleotide sequence analysis of the gene specifying the bifunctional 6'-aminoglycoside acetyltransferase 2"-aminoglycoside phosphotransferase enzyme in Streptococcus faecalis and identification and cloning of gene regions specifying the two activities.

Authors:  J J Ferretti; K S Gilmore; P Courvalin
Journal:  J Bacteriol       Date:  1986-08       Impact factor: 3.490

4.  Regulation of the pAD1 sex pheromone response in Enterococcus faecalis: construction and characterization of lacZ transcriptional fusions in a key control region of the plasmid.

Authors:  K E Weaver; D B Clewell
Journal:  J Bacteriol       Date:  1988-09       Impact factor: 3.490

5.  Mapping of Streptococcus faecalis plasmids pAD1 and pAD2 and studies relating to transposition of Tn917.

Authors:  D B Clewell; P K Tomich; M C Gawron-Burke; A E Franke; Y Yagi; F Y An
Journal:  J Bacteriol       Date:  1982-12       Impact factor: 3.490

6.  Conjugal transfer of plasmid-borne multiple antibiotic resistance in Streptococcus faecalis var. zymogenes.

Authors:  A E Jacob; S J Hobbs
Journal:  J Bacteriol       Date:  1974-02       Impact factor: 3.490

7.  Transferable resistance and aminoglycoside-modifying enzymes in enterococci.

Authors:  H Y Chen; J D Williams
Journal:  J Med Microbiol       Date:  1985-10       Impact factor: 2.472

8.  High-level resistance to gentamicin in clinical isolates of enterococci.

Authors:  B D Mederski-Samoraj; B E Murray
Journal:  J Infect Dis       Date:  1983-04       Impact factor: 5.226

9.  Effects of medium and inoculum variations on screening for high-level aminoglycoside resistance in Enterococcus faecalis.

Authors:  D F Sahm; C Torres
Journal:  J Clin Microbiol       Date:  1988-02       Impact factor: 5.948

10.  High-content aminoglycoside disks for determining aminoglycoside-penicillin synergy against Enterococcus faecalis.

Authors:  D F Sahm; C Torres
Journal:  J Clin Microbiol       Date:  1988-02       Impact factor: 5.948
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  5 in total

1.  Plasmid-borne high-level resistance to gentamicin in Enterococcus hirae, Enterococcus avium, and Enterococcus raffinosus.

Authors:  M Straut; G de Cespédès; T Horaud
Journal:  Antimicrob Agents Chemother       Date:  1996-05       Impact factor: 5.191

2.  A new high-level gentamicin resistance gene, aph(2'')-Id, in Enterococcus spp.

Authors:  S F Tsai; M J Zervos; D B Clewell; S M Donabedian; D F Sahm; J W Chow
Journal:  Antimicrob Agents Chemother       Date:  1998-05       Impact factor: 5.191

3.  Formation of potent hybrid promoters of the mutant llm gene by IS256 transposition in methicillin-resistant Staphylococcus aureus.

Authors:  H Maki; K Murakami
Journal:  J Bacteriol       Date:  1997-11       Impact factor: 3.490

4.  Tn5384, a composite enterococcal mobile element conferring resistance to erythromycin and gentamicin whose ends are directly repeated copies of IS256.

Authors:  L B Rice; L L Carias; S H Marshall
Journal:  Antimicrob Agents Chemother       Date:  1995-05       Impact factor: 5.191

5.  Prevalence of aac(6')-Ie-aph(2″)-Ia resistance gene and its linkage to Tn5281 in Enterococcus faecalis and Enterococcus faecium isolates from Tabriz hospitals.

Authors:  Amir Behnood; Safar Farajnia; Seyed Reza Moaddab; Shiva Ahdi-Khosroshahi; Aliakbar Katayounzadeh
Journal:  Iran J Microbiol       Date:  2013-09
  5 in total

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