Literature DB >> 8065300

Densely methylated DNA islands in mammalian chromosomal replication origins.

E S Tasheva1, D J Roufa.   

Abstract

Densely methylated DNA sequence islands, designated DMIs, have been observed in two Chinese hamster cell chromosomal replication origins by using a PCR-based chemical method of detection. One of the origins, oriS14, is located within or adjacent to the coding sequence for ribosomal protein S14 on chromosome 2q, and the other, ori-beta, is approximately 17 kbp downstream of the dhfr (dihydrofolic acid reductase) locus on chromosome 2p. The DMI in oriS14 is 127 bp long, and the DMI in ori-beta is 516 bp long. Both DMIs are bilaterally methylated (i.e., all dCs are modified to 5-methyl dC) only in cells that are replicating their DNA. When cell growth and DNA replication are arrested, methylation of CpA, CpT, and CpC dinucleotides is lost and the sequence islands display only a subset of their originally methylated CpG dinucleotides. Several possible roles for DMI-mediated regulation of mammalian chromosomal origins are considered.

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Year:  1994        PMID： 8065300      PMCID： PMC359088          DOI： 10.1128/mcb.14.9.5636-5644.1994

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  45 in total

Review 1.  Recent progress in understanding mechanisms of mammalian DNA amplification.

Authors:  G R Stark; M Debatisse; E Giulotto; G M Wahl
Journal:  Cell       Date:  1989-06-16       Impact factor: 41.582

2.  Mapping replication units in animal cells.

Authors:  S Handeli; A Klar; M Meuth; H Cedar
Journal:  Cell       Date:  1989-06-16       Impact factor: 41.582

3.  Timing and targeting: the biological functions of Dam methylation in E. coli.

Authors:  W Messer; M Noyer-Weidner
Journal:  Cell       Date:  1988-09-09       Impact factor: 41.582

4.  High-resolution mapping of replication fork movement through the amplified dihydrofolate reductase domain in CHO cells by in-gel renaturation analysis.

Authors:  T H Leu; J L Hamlin
Journal:  Mol Cell Biol       Date:  1989-02       Impact factor: 4.272

5.  Replication in the amplified dihydrofolate reductase domain in CHO cells may initiate at two distinct sites, one of which is a repetitive sequence element.

Authors:  B Anachkova; J L Hamlin
Journal:  Mol Cell Biol       Date:  1989-02       Impact factor: 4.272

6.  Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs.

Authors:  R R Meehan; J D Lewis; S McKay; E L Kleiner; A P Bird
Journal:  Cell       Date:  1989-08-11       Impact factor: 41.582

7.  Matrix attachment regions are positioned near replication initiation sites, genes, and an interamplicon junction in the amplified dihydrofolate reductase domain of Chinese hamster ovary cells.

Authors:  P A Dijkwel; J L Hamlin
Journal:  Mol Cell Biol       Date:  1988-12       Impact factor: 4.272

8.  Methylation of GATC sites is required for precise timing between rounds of DNA replication in Escherichia coli.

Authors:  A Bakker; D W Smith
Journal:  J Bacteriol       Date:  1989-10       Impact factor: 3.490

9.  The Drosophila melanogaster RPS17 gene encoding ribosomal protein S17.

Authors:  C Maki; D D Rhoads; M J Stewart; B Van Slyke; D J Roufa
Journal:  Gene       Date:  1989-07-15       Impact factor: 3.688

10.  The transcriptionally active human ribosomal protein S17 gene.

Authors:  I T Chen; D J Roufa
Journal:  Gene       Date:  1988-10-15       Impact factor: 3.688
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  19 in total

Review 1.  Human non-CG methylation: are human stem cells plant-like?

Authors:  Olga V Dyachenko; Tara V Schevchuk; Leo Kretzner; Yaroslav I Buryanov; Steven S Smith
Journal:  Epigenetics       Date:  2010-10-01       Impact factor: 4.528

2.  Concurrent replication and methylation at mammalian origins of replication.

Authors:  F D Araujo; J D Knox; M Szyf; G B Price; M Zannis-Hadjopoulos
Journal:  Mol Cell Biol       Date:  1998-06       Impact factor: 4.272

3.  Towards understanding the epigenetics of transcription by chromatin structure and the nuclear matrix.

Authors:  Rui Pires Martins; Stephen A Krawetz
Journal:  Gene Ther Mol Biol       Date:  2005

Review 4.  Identifying 5-methylcytosine and related modifications in DNA genomes.

Authors:  T Rein; M L DePamphilis; H Zorbas
Journal:  Nucleic Acids Res       Date:  1998-05-15       Impact factor: 16.971

5.  Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a.

Authors:  B H Ramsahoye; D Biniszkiewicz; F Lyko; V Clark; A P Bird; R Jaenisch
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-09       Impact factor: 11.205

6.  Novel pattern of DNA methylation in Neurospora crassa transgenic for the foreign gene hph.

Authors:  A C Codón; Y S Lee; V E Russo
Journal:  Nucleic Acids Res       Date:  1997-06-15       Impact factor: 16.971

7.  Identification of an origin of bidirectional DNA replication in the ubiquitously expressed mammalian CAD gene.

Authors:  R E Kelly; M L DeRose; B W Draper; G M Wahl
Journal:  Mol Cell Biol       Date:  1995-08       Impact factor: 4.272

8.  Site-specific initiation of DNA replication in Xenopus egg extract requires nuclear structure.

Authors:  D M Gilbert; H Miyazawa; M L DePamphilis
Journal:  Mol Cell Biol       Date:  1995-06       Impact factor: 4.272

9.  S1 SINE retroposons are methylated at symmetrical and non-symmetrical positions in Brassica napus: identification of a preferred target site for asymmetrical methylation.

Authors:  C Goubely; P Arnaud; C Tatout; J S Heslop-Harrison; J M Deragon
Journal:  Plant Mol Biol       Date:  1999-01       Impact factor: 4.076

Review 10.  The evolution of small DNA viruses of eukaryotes: past and present considerations.

Authors:  F F Shadan; L P Villarreal
Journal:  Virus Genes       Date:  1995       Impact factor: 2.332
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