Literature DB >> 8064294

Synthesis and structure-activity relationships of cytotoxic 7-hydroxy sterols.

C E Heltzel1, A A Gunatilaka, D G Kingston, G A Hofmann, R K Johnson.   

Abstract

The cytotoxic sterols 1 and 2, previously isolated from Pseudobersama mossambicensis, have been synthesized in nine steps from stigmasterol, together with seven related sterols. Structure-activity relationships of these sterols in cytotoxicity and DNA-damaging assays are discussed.

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Year:  1994        PMID： 8064294     DOI： 10.1021/np50107a009

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  5 in total

Review 1.  Review of progress in sterol oxidations: 1987-1995.

Authors:  L L Smith
Journal:  Lipids       Date:  1996-05       Impact factor: 1.880

2.  Acute toxicity study and antipyretic effect of the brown alga Turbinaria conoides (J. Agardh) Kuetz.

Authors:  S Sadish Kumar; Y Kumar; M S Y Khan; J Anbu; K G Sam
Journal:  Afr J Tradit Complement Altern Med       Date:  2009-05-07

3.  New α-Glucosidase Inhibitory Triterpenic Acid from Marine Macro Green Alga Codium dwarkense Boergs.

Authors:  Liaqat Ali; Abdul Latif Khan; Lubna Al-Kharusi; Javid Hussain; Ahmed Al-Harrasi
Journal:  Mar Drugs       Date:  2015-07-14       Impact factor: 5.118

4.  Antimicrobial and cytotoxic activities of turbinariaconoides (j.agardh) kuetz.

Authors:  Sadish Kumar Shanmugam; Yatendra Kumar; Khan Mohammad Sardaryar; Vivek Gupta; Erik De Clercq
Journal:  Iran J Pharm Res       Date:  2010       Impact factor: 1.696

5.  Oxysterols from a Marine Sponge Inflatella sp. and Their Action in 6-Hydroxydopamine-Induced Cell Model of Parkinson's Disease.

Authors:  Sophia A Kolesnikova; Ekaterina G Lyakhova; Anatoly I Kalinovsky; Roman S Popov; Ekaterina A Yurchenko; Valentin A Stonik
Journal:  Mar Drugs       Date:  2018-11-21       Impact factor: 5.118
  5 in total

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