Literature DB >> 8059600

Distribution of prion protein in German patients with Creutzfeldt-Jakob disease is different from that in Japanese patients.

R Doi-Yi1, T Kitamoto, K Ogomori, P Mehraein, J Tateishi.   

Abstract

We investigated the distribution of prion protein (PrP) in 14 German patients with sporadic Creutzfeldt-Jakob disease (CJD) and compared it with that observed in Japanese patients. Immunohistochemical study revealed diffuse gray matter stainings including synaptic structures in all cases. In addition, 4 patients showed plaque-type deposition which was very rarely observed among sporadic Japanese patients without known mutation of the PrP gene but with valine at codon 129. A higher incidence of PrP plaques in German sporadic CJD may be related to the racial difference in the PrP gene.

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Year:  1994        PMID： 8059600     DOI： 10.1007/bf00294174

Source DB:  PubMed          Journal:  Acta Neuropathol        ISSN： 0001-6322            Impact factor:   17.088


  20 in total

1.  The primary structure of the prion protein influences the distribution of abnormal prion protein in the central nervous system.

Authors:  T Kitamoto; K Doh-ura; T Muramoto; M Miyazono; J Tateishi
Journal:  Am J Pathol       Date:  1992-08       Impact factor: 4.307

2.  New mutation in scrapie amyloid precursor gene (at codon 178) in Finnish Creutzfeldt-Jakob kindred.

Authors:  L G Goldfarb; M Haltia; P Brown; A Nieto; J Kovanen; W R McCombie; S Trapp; D C Gajdusek
Journal:  Lancet       Date:  1991-02-16       Impact factor: 79.321

3.  N-terminal sequence of prion protein is also integrated into kuru plaques in patients with Gerstmann-Sträussler syndrome.

Authors:  T Kitamoto; T Muramoto; C Hilbich; K Beyreuther; J Tateishi
Journal:  Brain Res       Date:  1991-04-05       Impact factor: 3.252

4.  Mutations in familial Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker's syndrome.

Authors:  D Goldgaber; L G Goldfarb; P Brown; D M Asher; W T Brown; S Lin; J W Teener; S M Feinstone; R Rubenstein; R J Kascsak
Journal:  Exp Neurol       Date:  1989-11       Impact factor: 5.330

5.  Homozygous prion protein genotype predisposes to sporadic Creutzfeldt-Jakob disease.

Authors:  M S Palmer; A J Dryden; J T Hughes; J Collinge
Journal:  Nature       Date:  1991-07-25       Impact factor: 49.962

6.  Mutation of the prion protein in Libyan Jews with Creutzfeldt-Jakob disease.

Authors:  K Hsiao; Z Meiner; E Kahana; C Cass; I Kahana; D Avrahami; G Scarlato; O Abramsky; S B Prusiner; R Gabizon
Journal:  N Engl J Med       Date:  1991-04-18       Impact factor: 91.245

7.  Immunochemical, molecular genetic, and transmission studies on a case of Gerstmann-Sträussler-Scheinker syndrome.

Authors:  J Tateishi; T Kitamoto; K Doh-ura; Y Sakaki; G Steinmetz; C Tranchant; J M Warter; N Heldt
Journal:  Neurology       Date:  1990-10       Impact factor: 9.910

8.  Creutzfeldt-Jakob disease patients with congophilic kuru plaques have the missense variant prion protein common to Gerstmann-Sträussler syndrome.

Authors:  K Doh-ura; J Tateishi; T Kitamoto; H Sasaki; Y Sakaki
Journal:  Ann Neurol       Date:  1990-02       Impact factor: 10.422

9.  Abnormal isoform of prion proteins accumulates in the synaptic structures of the central nervous system in patients with Creutzfeldt-Jakob disease.

Authors:  T Kitamoto; R W Shin; K Doh-ura; N Tomokane; M Miyazono; T Muramoto; J Tateishi
Journal:  Am J Pathol       Date:  1992-06       Impact factor: 4.307

10.  Creutzfeldt-Jakob disease with codon 129 polymorphism (valine): a comparative study of patients with codon 102 point mutation or without mutations.

Authors:  M Miyazono; T Kitamoto; K Doh-ura; T Iwaki; J Tateishi
Journal:  Acta Neuropathol       Date:  1992       Impact factor: 17.088
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