| Literature DB >> 8058763 |
M Eckwalanga1, M Marussig, M D Tavares, J C Bouanga, E Hulier, J H Pavlovitch, P Minoprio, D Portnoï, L Rénia, D Mazier.
Abstract
The retrovirus LP-BM5 murine leukemia virus induces murine AIDS in C57BL/6 mice that has many similarities with human AIDS; Plasmodium berghei ANKA causes experimental cerebral malaria in the same strain of mice. The outcome of malaria infection was studied in mice concurrently infected with the two pathogens. The retrovirus significantly reduced the gravity of the neurological manifestations associated with Plasmodium berghei ANKA infection. The protection against experimental cerebral malaria induced by murine AIDS increased with duration of viral infection and, hence, with the severity of the immunodeficiency. Interleukin 10, principally from splenic T cells, was shown to play a crucial role in this protection.Entities:
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Year: 1994 PMID： 8058763 PMCID： PMC44552 DOI： 10.1073/pnas.91.17.8097
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205