| Literature DB >> 9712753 |
V Amani1, M I Boubou, S Pied, M Marussig, D Walliker, D Mazier, L Rénia.
Abstract
Infection with Plasmodium berghei ANKA is usually lethal. The parasite causes in some mouse strains a neurovascular syndrome, experimental cerebral malaria (ECM), involving immunopathological reactions. The effects on the development of ECM of the mouse genetic background have been clearly demonstrated, but nothing is known about the effects of the clonal diversity of the parasite. We showed that various cloned lines derived from a polyclonal line of P. berghei ANKA caused ECM but that the extent of ECM induction was dependent on the amount of inoculum. Subtle differences in ECM characteristics (survival time and hypothermia) were also observed. We also confirmed, using the 1.49L cloned line, that the mouse genetic background strongly affects ECM.Entities:
Mesh:
Year: 1998 PMID: 9712753 PMCID: PMC108491 DOI: 10.1128/IAI.66.9.4093-4099.1998
Source DB: PubMed Journal: Infect Immun ISSN: 0019-9567 Impact factor: 3.441