BACKGROUND: While cognitive and functional deficits are the hallmark of Alzheimer's disease (AD), loss of social function (and the dependence this implies) is also critical, especially in early stages of disease. Little attention has been directed to this facet of dementing disease. We describe a scale for assessing dependency in AD and present a baseline profile of dependency in a cohort of AD patients. METHODS: In a study of the predictors of the course of AD, 233 patients in early stages of disease (modified MMS > or = 30) were assessed. Psychometric properties of the dependence scale were established. To validate the scale, dependence scores at baseline were correlated with a series of measures assessing cognition and function. The course of dependency over 18 months of follow-up was also analyzed. RESULTS: The scale shows adequate reliability (test-retest, intraclass correlation). Dependence stage was related to other measures of disease severity. Scalogram analysis shows that the dependence scale is consistent with the course of functional loss established for dementing disease. Prospective data indicate sensitivity of the scale to disease progression. CONCLUSION: Dependency is a distinct, measurable component of dementing disease and should be considered an important outcome in studies of AD.
BACKGROUND: While cognitive and functional deficits are the hallmark of Alzheimer's disease (AD), loss of social function (and the dependence this implies) is also critical, especially in early stages of disease. Little attention has been directed to this facet of dementing disease. We describe a scale for assessing dependency in AD and present a baseline profile of dependency in a cohort of ADpatients. METHODS: In a study of the predictors of the course of AD, 233 patients in early stages of disease (modified MMS > or = 30) were assessed. Psychometric properties of the dependence scale were established. To validate the scale, dependence scores at baseline were correlated with a series of measures assessing cognition and function. The course of dependency over 18 months of follow-up was also analyzed. RESULTS: The scale shows adequate reliability (test-retest, intraclass correlation). Dependence stage was related to other measures of disease severity. Scalogram analysis shows that the dependence scale is consistent with the course of functional loss established for dementing disease. Prospective data indicate sensitivity of the scale to disease progression. CONCLUSION: Dependency is a distinct, measurable component of dementing disease and should be considered an important outcome in studies of AD.
Authors: Somaia Mohamed; Robert Rosenheck; Constantine G Lyketsos; Richard Kaczynski; David L Sultzer; Lon S Schneider Journal: J Clin Psychiatry Date: 2011-09-06 Impact factor: 4.384
Authors: Eric Stallard; Bruce Kinosian; Arthur S Zbrozek; Anatoliy I Yashin; Henry A Glick; Yaakov Stern Journal: Med Decis Making Date: 2010 Nov-Dec Impact factor: 2.583
Authors: C W Zhu; C Leibman; R Townsend; T McLaughlin; N Scarmeas; M Albert; J Brandt; D Blacker; M Sano; Y Stern Journal: J Nutr Health Aging Date: 2009-03 Impact factor: 4.075
Authors: Maurice W Dysken; Mary Sano; Sanjay Asthana; Julia E Vertrees; Muralidhar Pallaki; Maria Llorente; Susan Love; Gerard D Schellenberg; J Riley McCarten; Julie Malphurs; Susana Prieto; Peijun Chen; David J Loreck; George Trapp; Rajbir S Bakshi; Jacobo E Mintzer; Judith L Heidebrink; Ana Vidal-Cardona; Lillian M Arroyo; Angel R Cruz; Sally Zachariah; Neil W Kowall; Mohit P Chopra; Suzanne Craft; Stephen Thielke; Carolyn L Turvey; Catherine Woodman; Kimberly A Monnell; Kimberly Gordon; Julie Tomaska; Yoav Segal; Peter N Peduzzi; Peter D Guarino Journal: JAMA Date: 2014-01-01 Impact factor: 56.272
Authors: Stephanie Cosentino; Laura B Zahodne; Jason Brandt; Deborah Blacker; Marilyn Albert; Bruno Dubois; Yaakov Stern Journal: Alzheimers Dement Date: 2014-03-18 Impact factor: 21.566
Authors: Maurice W Dysken; Peter D Guarino; Julia E Vertrees; Sanjay Asthana; Mary Sano; Maria Llorente; Muralidhar Pallaki; Susan Love; Gerard D Schellenberg; J Riley McCarten; Julie Malphurs; Susana Prieto; Peijun Chen; David J Loreck; Sara Carney; George Trapp; Rajbir S Bakshi; Jacobo E Mintzer; Judith L Heidebrink; Ana Vidal-Cardona; Lillian M Arroyo; Angel R Cruz; Neil W Kowall; Mohit P Chopra; Suzanne Craft; Stephen Thielke; Carolyn L Turvey; Catherine Woodman; Kimberly A Monnell; Kimberly Gordon; Julie Tomaska; Govind Vatassery Journal: Alzheimers Dement Date: 2013-04-11 Impact factor: 21.566
Authors: Carolyn W Zhu; Christopher Leibman; Trent McLaughlin; Nikolaos Scarmeas; Marilyn Albert; Jason Brandt; Deborah Blacker; Mary Sano; Yaakov Stern Journal: J Am Geriatr Soc Date: 2008-07-24 Impact factor: 5.562