Literature DB >> 8053502

High tissue content of soluble beta 1-40 is linked to cerebral amyloid angiopathy.

N Suzuki1, T Iwatsubo, A Odaka, Y Ishibashi, C Kitada, Y Ihara.   

Abstract

We developed two highly sensitive enzyme immunoassays for beta-protein with different specificities. One is specific for beta 1-40, while the other is equally sensitive to beta 1-38, beta 1-39, beta 1-40, and beta 1-42. With the enzyme immunoassays we investigated whether the soluble fraction from brain tissue contains beta 1-40 or other species of beta-protein. Aged control and Alzheimer's diseased brains showed highly variable values of beta 1-40, which was found to be the major beta species in their extracts. High tissue content of soluble beta 1-40 was not correlated to the abundance of senile plaques but was invariably associated with cerebral amyloid angiopathy. Thus, the tissue level of soluble beta 1-40 should be useful for the quantification of cerebral amyloid angiopathy.

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Year:  1994        PMID： 8053502      PMCID： PMC1887395     

Source DB:  PubMed          Journal:  Am J Pathol        ISSN： 0002-9440            Impact factor:   4.307


  31 in total

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Review 2.  The molecular pathology of Alzheimer's disease.

Authors:  D J Selkoe
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3.  Mis-sense mutation Val----Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease.

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Journal:  Lancet       Date:  1991-04-20       Impact factor: 79.321

4.  The presence of a novel protein in calf serum that recognizes beta amyloid in the formalin-fixed section.

Authors:  K Kanemaru; M Hasegawa; H Shimada; Y Ihara
Journal:  Am J Pathol       Date:  1990-09       Impact factor: 4.307

5.  Reversible in vitro growth of Alzheimer disease beta-amyloid plaques by deposition of labeled amyloid peptide.

Authors:  J E Maggio; E R Stimson; J R Ghilardi; C J Allen; C E Dahl; D C Whitcomb; S R Vigna; H V Vinters; M E Labenski; P W Mantyh
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-15       Impact factor: 11.205

6.  Amyloid beta-peptide is produced by cultured cells during normal metabolism.

Authors:  C Haass; M G Schlossmacher; A Y Hung; C Vigo-Pelfrey; A Mellon; B L Ostaszewski; I Lieberburg; E H Koo; D Schenk; D B Teplow
Journal:  Nature       Date:  1992-09-24       Impact factor: 49.962

7.  Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids.

Authors:  P Seubert; C Vigo-Pelfrey; F Esch; M Lee; H Dovey; D Davis; S Sinha; M Schlossmacher; J Whaley; C Swindlehurst
Journal:  Nature       Date:  1992-09-24       Impact factor: 49.962

8.  Mass spectrometry of purified amyloid beta protein in Alzheimer's disease.

Authors:  H Mori; K Takio; M Ogawara; D J Selkoe
Journal:  J Biol Chem       Date:  1992-08-25       Impact factor: 5.157

9.  Production of the Alzheimer amyloid beta protein by normal proteolytic processing.

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Journal:  Science       Date:  1992-10-02       Impact factor: 47.728

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Authors:  A E Roher; J D Lowenson; S Clarke; C Wolkow; R Wang; R J Cotter; I M Reardon; H A Zürcher-Neely; R L Heinrikson; M J Ball
Journal:  J Biol Chem       Date:  1993-02-15       Impact factor: 5.157
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  50 in total

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Authors:  Jeong Hyun Lee; Brian J Bacskai; Cenk Ayata
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3.  Prediction and longitudinal study of CSF biomarkers in mild cognitive impairment.

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Journal:  Neurobiol Aging       Date:  2007-09-24       Impact factor: 4.673

4.  High levels of circulating beta-amyloid peptide do not cause cerebral beta-amyloidosis in transgenic mice.

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Journal:  Am J Pathol       Date:  1996-07       Impact factor: 4.307

Review 5.  Interactions of β-amyloid peptide with fibrinogen and coagulation factor XII may contribute to Alzheimer's disease.

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6.  β-Amyloid 42/40 ratio and kalirin expression in Alzheimer disease with psychosis.

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Journal:  Neurobiol Aging       Date:  2012-03-17       Impact factor: 4.673

Review 7.  Expression and Processing of Amyloid Precursor Protein in Vascular Endothelium.

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8.  Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta.

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Journal:  J Neurosci       Date:  2005-01-19       Impact factor: 6.167

9.  Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer.

Authors:  J B Mackic; M Stins; J G McComb; M Calero; J Ghiso; K S Kim; S D Yan; D Stern; A M Schmidt; B Frangione; B V Zlokovic
Journal:  J Clin Invest       Date:  1998-08-15       Impact factor: 14.808

10.  Diabetes and Alzheimer's disease - is there a connection?

Authors:  Anders A F Sima; Zhen-Guo Li
Journal:  Rev Diabet Stud       Date:  2007-02-10
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