Literature DB >> 27927802

Expression and Processing of Amyloid Precursor Protein in Vascular Endothelium.

Livius V d'Uscio1, Tongrong He1, Zvonimir S Katusic1.   

Abstract

Amyloid precursor protein (APP) is evolutionary conserved protein expressed in endothelial cells of cerebral and peripheral arteries. In this review, we discuss mechanisms responsible for expression and proteolytic cleavage of APP in endothelial cells. We focus on physiological and pathological implications of APP expression in vascular endothelium. ©2017 Int. Union Physiol. Sci./Am. Physiol. Soc.

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Year:  2017        PMID： 27927802      PMCID： PMC5338593          DOI： 10.1152/physiol.00021.2016

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  199 in total

1.  Cerebral microvascular amyloid beta protein deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant amyloid beta precursor protein.

Authors:  Jianting Miao; Feng Xu; Judianne Davis; Irene Otte-Höller; Marcel M Verbeek; William E Van Nostrand
Journal:  Am J Pathol       Date:  2005-08       Impact factor: 4.307

2.  Differences between vascular and plaque core amyloid in Alzheimer's disease.

Authors:  F Prelli; E Castaño; G G Glenner; B Frangione
Journal:  J Neurochem       Date:  1988-08       Impact factor: 5.372

3.  Beta-amyloid mediated nitration of manganese superoxide dismutase: implication for oxidative stress in a APPNLH/NLH X PS-1P264L/P264L double knock-in mouse model of Alzheimer's disease.

Authors:  Muthuswamy Anantharaman; Jitbanjong Tangpong; Jeffery N Keller; Michael P Murphy; William R Markesbery; Kelley K Kiningham; Daret K St Clair
Journal:  Am J Pathol       Date:  2006-05       Impact factor: 4.307

4.  Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines.

Authors:  R De Caterina; P Libby; H B Peng; V J Thannickal; T B Rajavashisth; M A Gimbrone; W S Shin; J K Liao
Journal:  J Clin Invest       Date:  1995-07       Impact factor: 14.808

5.  Traffic jam at the blood-brain barrier promotes greater accumulation of Alzheimer's disease amyloid-β proteins in the cerebral vasculature.

Authors:  Edward K Agyare; Sarah R Leonard; Geoffry L Curran; Caroline C Yu; Val J Lowe; Anant K Paravastu; Joseph F Poduslo; Karunya K Kandimalla
Journal:  Mol Pharm       Date:  2013-03-05       Impact factor: 4.939

6.  Activation of PPARδ prevents endothelial dysfunction induced by overexpression of amyloid-β precursor protein.

Authors:  Livius V d'Uscio; Pritam Das; Anantha V R Santhanam; Tongrong He; Steven G Younkin; Zvonimir S Katusic
Journal:  Cardiovasc Res       Date:  2012-08-10       Impact factor: 10.787

7.  Vasoactive effects of A beta in isolated human cerebrovessels and in a transgenic mouse model of Alzheimer's disease: role of inflammation.

Authors:  Daniel Paris; James Humphrey; Amita Quadros; Nikunj Patel; Robert Crescentini; Fiona Crawford; Michael Mullan
Journal:  Neurol Res       Date:  2003-09       Impact factor: 2.448

8.  Amyloid precursor protein mediates a tyrosine kinase-dependent activation response in endothelial cells.

Authors:  Susan A Austin; Mary A Sens; Colin K Combs
Journal:  J Neurosci       Date:  2009-11-18       Impact factor: 6.167

9.  Ischemic conditions and ß-secretase activation: The impact of membrane cholesterol enrichment as triggering factor in rat brain endothelial cells.

Authors:  Anna Brambillaa; Elena Lonati; Chiara Milani; Angela Maria Rizzo; Francesca Farina; Laura Botto; Massimo Masserini; Paola Palestini; Alessandra Bulbarelli
Journal:  Int J Biochem Cell Biol       Date:  2015-12       Impact factor: 5.085

10.  BACE-1 is expressed in the blood-brain barrier endothelium and is upregulated in a murine model of Alzheimer's disease.

Authors:  Kavi Devraj; Slobodan Poznanovic; Christoph Spahn; Gerhard Schwall; Patrick N Harter; Michel Mittelbronn; Katia Antoniello; Paolo Paganetti; Andreas Muhs; Mike Heilemann; Richard A Hawkins; André Schrattenholz; Stefan Liebner
Journal:  J Cereb Blood Flow Metab       Date:  2015-10-13       Impact factor: 6.200
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  22 in total

1.  Endothelium-specific amyloid precursor protein deficiency causes endothelial dysfunction in cerebral arteries.

Authors:  Livius V d'Uscio; Tongrong He; Anantha V Santhanam; Zvonimir S Katusic
Journal:  J Cereb Blood Flow Metab       Date:  2017-09-29       Impact factor: 6.200

Review 2.  Neurovascular and Cognitive Dysfunction in Hypertension.

Authors:  Costantino Iadecola; Rebecca F Gottesman
Journal:  Circ Res       Date:  2019-03-29       Impact factor: 17.367

3.  Impairment of amyloid precursor protein alpha-processing in cerebral microvessels of type 1 diabetic mice.

Authors:  Tongrong He; Ruohan Sun; Anantha Vr Santhanam; Livius V d'Uscio; Tong Lu; Zvonimir S Katusic
Journal:  J Cereb Blood Flow Metab       Date:  2017-12-18       Impact factor: 6.200

4.  Characterization of Glycolytic Enzymes and Pyruvate Kinase M2 in Type 1 and 2 Diabetic Nephropathy.

Authors:  Daniel Gordin; Hetal Shah; Takanori Shinjo; Ronald St-Louis; Weier Qi; Kyoungmin Park; Samantha M Paniagua; David M Pober; I-Hsien Wu; Vanessa Bahnam; Megan J Brissett; Liane J Tinsley; Jonathan M Dreyfuss; Hui Pan; Yutong Dong; Monika A Niewczas; Peter Amenta; Thorsten Sadowski; Aimo Kannt; Hillary A Keenan; George L King
Journal:  Diabetes Care       Date:  2019-05-10       Impact factor: 19.112

5.  Partial loss of endothelial nitric oxide leads to increased cerebrovascular beta amyloid.

Authors:  Susan A Austin; Zvonimir S Katusic
Journal:  J Cereb Blood Flow Metab       Date:  2019-01-07       Impact factor: 6.200

6.  Vascular phenotype of amyloid precursor protein-deficient mice.

Authors:  Livius V d'Uscio; Zvonimir S Katusic
Journal:  Am J Physiol Heart Circ Physiol       Date:  2019-03-22       Impact factor: 4.733

7.  Inactivation of BACE1 increases expression of endothelial nitric oxide synthase in cerebrovascular endothelium.

Authors:  Tongrong He; Livius V d'Uscio; Ruohan Sun; Anantha Vijay R Santhanam; Zvonimir S Katusic
Journal:  J Cereb Blood Flow Metab       Date:  2022-06-08       Impact factor: 6.960

Review 8.  The relationship between amyloid-beta and brain capillary endothelial cells in Alzheimer's disease.

Authors:  Yan-Li Zhang; Juan Wang; Zhi-Na Zhang; Qiang Su; Jun-Hong Guo
Journal:  Neural Regen Res       Date:  2022-11       Impact factor: 6.058

9.  Endothelial expression of human amyloid precursor protein leads to amyloid β in the blood and induces cerebral amyloid angiopathy in knock-in mice.

Authors:  Yuriko Tachida; Saori Miura; Yui Muto; Hiroyuki Takuwa; Naruhiko Sahara; Akihiro Shindo; Yukio Matsuba; Takashi Saito; Naoyuki Taniguchi; Yasushi Kawaguchi; Hidekazu Tomimoto; Takaomi Saido; Shinobu Kitazume
Journal:  J Biol Chem       Date:  2022-03-31       Impact factor: 5.486

10.  Endothelium-specific deletion of amyloid-β precursor protein exacerbates endothelial dysfunction induced by aging.

Authors:  Livius V d'Uscio; Zvonimir S Katusic
Journal:  Aging (Albany NY)       Date:  2021-08-12       Impact factor: 5.682
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