| Literature DB >> 8053029 |
P A Kager1, M J Schultz, E E Zijlstra, B van den Berg, C J van Boxtel.
Abstract
The recently developed artemisinin derivative arteether was administered by intramuscular injection to healthy male subjects in a single dose (n = 23) and a multiple dose study (n = 27). The drug was well tolerated. Clinical, neurological, electrocardiographic and biochemical monitoring did not reveal significant toxicity. Apart from some increase in eosinophil numbers, no haematological abnormality was seen. Preliminary pharmacokinetic data showed a long elimination half life of 25-72 h and marked accumulation in the multiple dose study.Entities:
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Year: 1994 PMID： 8053029 DOI： 10.1016/0035-9203(94)90475-8
Source DB: PubMed Journal: Trans R Soc Trop Med Hyg ISSN： 0035-9203 Impact factor: 2.184