Literature DB >> 8053027

Clinical trials of artemisinin and its derivatives in the treatment of malaria in China.

G Q Li1, X B Guo, L C Fu, H X Jian, X H Wang.   

Abstract

Since 1979 several derivatives of artemisinin have been synthesized and studied in China. Artemisinin suppositories, artesunate (oral or parenteral), intramuscular artemether and dihydroartemisinin tablets have all proved rapidly effective. In all, 2352 patients (2150 with Plasmodium falciparum and 202 with P. vivax) have been included in clinical trials from our centre. All preparations have been well tolerated. These drugs have now replaced chloroquine and quinine for the treatment of malaria in China.

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Year:  1994        PMID： 8053027     DOI： 10.1016/0035-9203(94)90460-x

Source DB:  PubMed          Journal:  Trans R Soc Trop Med Hyg        ISSN： 0035-9203            Impact factor:   2.184


  34 in total

1.  Sensitivity to artemisinin, mefloquine and quinine of Plasmodium falciparum in northwestern Thailand.

Authors:  Felix Hüttinger; Wichai Satimai; Gunther Wernsdorfer; Ursula Wiedermann; Kanungnit Congpuong; Walther H Wernsdorfer
Journal:  Wien Klin Wochenschr       Date:  2010-10       Impact factor: 1.704

Review 2.  Recent clinical and molecular insights into emerging artemisinin resistance in Plasmodium falciparum.

Authors:  Connor O'Brien; Philipp P Henrich; Neha Passi; David A Fidock
Journal:  Curr Opin Infect Dis       Date:  2011-12       Impact factor: 4.915

Review 3.  The role of plant-derived drugs and herbal medicines in healthcare.

Authors:  P A De Smet
Journal:  Drugs       Date:  1997-12       Impact factor: 9.546

4.  Evaluation of antimalarial resistance marker polymorphism in returned migrant workers in China.

Authors:  Jun Feng; Jun Li; He Yan; Xinyu Feng; Zhigui Xia
Journal:  Antimicrob Agents Chemother       Date:  2014-10-27       Impact factor: 5.191

Review 5.  Malaria biology and disease pathogenesis: insights for new treatments.

Authors:  Louis H Miller; Hans C Ackerman; Xin-zhuan Su; Thomas E Wellems
Journal:  Nat Med       Date:  2013-02-06       Impact factor: 53.440

6.  Comparative clinical trial of two-fixed combinations dihydroartemisinin-napthoquine-trimethoprim (DNP) and artemether-lumefantrine (Coartem/Riamet) in the treatment of acute uncomplicated falciparum malaria in Thailand.

Authors:  S Krudsood; K Chalermrut; C Pengruksa; S Srivilairit; U Silachamroon; S Treeprasertsuk; S Kano; G M Brittenham; S Looareesuwan
Journal:  Southeast Asian J Trop Med Public Health       Date:  2003-06       Impact factor: 0.267

7.  Artemisinin resistance phenotypes and K13 inheritance in a Plasmodium falciparum cross and Aotus model.

Authors:  Juliana M Sá; Sarah R Kaslow; Michael A Krause; Viviana A Melendez-Muniz; Rebecca E Salzman; Whitney A Kite; Min Zhang; Roberto R Moraes Barros; Jianbing Mu; Paul K Han; J Patrick Mershon; Christine E Figan; Ramoncito L Caleon; Rifat S Rahman; Tyler J Gibson; Chanaki Amaratunga; Erika P Nishiguchi; Kimberly F Breglio; Theresa M Engels; Soundarapandian Velmurugan; Stacy Ricklefs; Judith Straimer; Nina F Gnädig; Bingbing Deng; Anna Liu; Ababacar Diouf; Kazutoyo Miura; Gregory S Tullo; Richard T Eastman; Sumana Chakravarty; Eric R James; Kenneth Udenze; Suzanne Li; Daniel E Sturdevant; Robert W Gwadz; Stephen F Porcella; Carole A Long; David A Fidock; Marvin L Thomas; Michael P Fay; B Kim Lee Sim; Stephen L Hoffman; John H Adams; Rick M Fairhurst; Xin-Zhuan Su; Thomas E Wellems
Journal:  Proc Natl Acad Sci U S A       Date:  2018-11-19       Impact factor: 11.205

8.  Safety of artemether-lumefantrine in pregnant women with malaria: results of a prospective cohort study in Zambia.

Authors:  Christine Manyando; Rhoda Mkandawire; Lwipa Puma; Moses Sinkala; Evans Mpabalwani; Eric Njunju; Melba Gomes; Isabela Ribeiro; Verena Walter; Mailis Virtanen; Raymond Schlienger; Marc Cousin; Miriam Chipimo; Frank M Sullivan
Journal:  Malar J       Date:  2010-09-01       Impact factor: 2.979

9.  Randomized control trial of quinine and artesunate in complicated malaria.

Authors:  Anil Kumar Mohanty; B K Rath; R Mohanty; A K Samal; K Mishra
Journal:  Indian J Pediatr       Date:  2004-04       Impact factor: 1.967

10.  Pharmacokinetics, tissue distribution and mass balance of radiolabeled dihydroartemisinin in male rats.

Authors:  Lisa H Xie; Qigui Li; Jing Zhang; Peter J Weina
Journal:  Malar J       Date:  2009-05-26       Impact factor: 2.979
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