| Literature DB >> 20924699 |
Felix Hüttinger1, Wichai Satimai, Gunther Wernsdorfer, Ursula Wiedermann, Kanungnit Congpuong, Walther H Wernsdorfer.
Abstract
The increasing drug resistance of Plasmodium falciparum is a worldwide problem. The objective of the study was the assessment of the in vitro activity of artemisinin, mefloquine and quinine, in an area where P. falciparum is multi-drug resistant. The sensitivity tests were based on measuring the drug-dependent inhibition of schizont maturation. For the 43 successfully tested isolates the mean effective concentrations (IC(50) and IC(90)) for artemisinin were 0.0081 and 0.1372 μM, respectively. For mefloquine the IC(50) was 0.1260 μM and the IC(90) was 3.7345 μM. Quinine showed an IC(50) of 0.2155 μM and an IC(90) of 2.5040 μM. All tested drugs showed a significant reduction in the effectiveness, compared with the results of former years. This suggests a further rise of resistance of local P. falciparum, which is alarming especially for artemisinin and quinine.Entities:
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Year: 2010 PMID： 20924699 DOI： 10.1007/s00508-010-1438-6
Source DB: PubMed Journal: Wien Klin Wochenschr ISSN： 0043-5325 Impact factor: 1.704