Literature DB >> 8047140

Mechanism of activation of the TGF-beta receptor.

J L Wrana1, L Attisano, R Wieser, F Ventura, J Massagué.   

Abstract

Transforming growth factor-beta (TGF-beta) signals by contacting two distantly related transmembrane serine/threonine kinases called receptors I and II. The role of these molecules in signalling has now been determined. TGF-beta binds directly to receptor II, which is a constitutively active kinase. Bound TGF-beta is then recognized by receptor I which is recruited into the complex and becomes phosphorylated by receptor II. Phosphorylation allows receptor I to propagate the signal to downstream substrates. This provides a mechanism by which a cytokine can generate the first step of a signalling cascade.

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Year:  1994        PMID： 8047140     DOI： 10.1038/370341a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  519 in total

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