Literature DB >> 8041779

Physical association of JAK1 and JAK2 tyrosine kinases with the interleukin 2 receptor beta and gamma chains.

N Tanaka1, H Asao, K Ohbo, N Ishii, T Takeshita, M Nakamura, H Sasaki, K Sugamura.   

Abstract

The functional interleukin 2 (IL-2) receptors contain the beta and gamma chains which are necessary for the transduction of cell growth signals. Monoclonal antibodies specific for the beta chain and gamma chain coimmunoprecipitated JAK1 and 114-kDa JAK2 tyrosine kinases, respectively. Tyrosine phosphorylation of JAK1 and JAK2 was induced upon IL-2 stimulation, and IL-2 activated the JAK2 kinase. These results demonstrate that the JAK1 and JAK2 tyrosine kinases are physically associated with the beta chain and gamma chain, respectively, and suggest that regulation of the kinases may be linked to IL-2-induced signal transduction.

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Year:  1994        PMID： 8041779      PMCID： PMC44381          DOI： 10.1073/pnas.91.15.7271

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  36 in total

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8.  Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes.

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Journal:  Science       Date:  1994-03-11       Impact factor: 47.728

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  7 in total

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Journal:  Clin Diagn Lab Immunol       Date:  1995-09

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Authors:  B H Nelson; B C McIntosh; L L Rosencrans; P D Greenberg
Journal:  Proc Natl Acad Sci U S A       Date:  1997-03-04       Impact factor: 11.205

4.  A membrane-proximal region of the interleukin-2 receptor gamma c chain sufficient for Jak kinase activation and induction of proliferation in T cells.

Authors:  B H Nelson; J D Lord; P D Greenberg
Journal:  Mol Cell Biol       Date:  1996-01       Impact factor: 4.272

5.  The molecular role of the common gamma c subunit in signal transduction reveals functional asymmetry within multimeric cytokine receptor complexes.

Authors:  S Y Lai; W Xu; S L Gaffen; K D Liu; G D Longmore; W C Greene; M A Goldsmith
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Authors:  C Beadling; J Ng; J W Babbage; D A Cantrell
Journal:  EMBO J       Date:  1996-04-15       Impact factor: 11.598

7.  Endocytosis of interleukin 2 receptors in human T lymphocytes: distinct intracellular localization and fate of the receptor alpha, beta, and gamma chains.

Authors:  A Hémar; A Subtil; M Lieb; E Morelon; R Hellio; A Dautry-Varsat
Journal:  J Cell Biol       Date:  1995-04       Impact factor: 10.539
  7 in total

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