Literature DB >> 8128231

Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes.

M Kondo1, T Takeshita, M Higuchi, M Nakamura, T Sudo, S Nishikawa, K Sugamura.   

Abstract

The gamma chain of the interleukin-2 (IL-2) receptor is shared with the functional IL-4 receptor and is causatively related to X-linked severe combined immunodeficiency (XSCID), which is ascribed to a profound T cell defect. Studies with monoclonal antibodies specific for the IL-2 receptor gamma chain showed that the gamma chain participates in the functional high-affinity receptor complexes for IL-7 that are involved in the differentiation of T and B cells. Participation of the gamma subunit in more than one receptor may enable the elucidation of the mechanisms of XSCID development and lymphocyte differentiation.

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Year:  1994        PMID： 8128231     DOI： 10.1126/science.8128231

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  81 in total

1.  Interleukin 7 receptor-deficient mice lack gammadelta T cells.

Authors:  K Maki; S Sunaga; Y Komagata; Y Kodaira; A Mabuchi; H Karasuyama; K Yokomuro; J I Miyazaki; K Ikuta
Journal:  Proc Natl Acad Sci U S A       Date:  1996-07-09       Impact factor: 11.205

2.  Effect of Anti-IL-15 Administration on T Cell and NK Cell Homeostasis in Rhesus Macaques.

Authors:  Maren Q DeGottardi; Afam A Okoye; Mukta Vaidya; Aarthi Talla; Audrie L Konfe; Matthew D Reyes; Joseph A Clock; Derick M Duell; Alfred W Legasse; Amit Sabnis; Byung S Park; Michael K Axthelm; Jacob D Estes; Keith A Reiman; Rafick-Pierre Sekaly; Louis J Picker
Journal:  J Immunol       Date:  2016-07-18       Impact factor: 5.422

3.  Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling.

Authors:  Yrina Rochman; Mohit Kashyap; Gertraud W Robinson; Kazuhito Sakamoto; Julio Gomez-Rodriguez; Kay-Uwe Wagner; Warren J Leonard
Journal:  Proc Natl Acad Sci U S A       Date:  2010-10-25       Impact factor: 11.205

4.  Evidence for a critical role for the cytoplasmic region of the interleukin 2 (IL-2) receptor gamma chain in IL-2, IL-4, and IL-7 signalling.

Authors:  A Kawahara; Y Minami; T Taniguchi
Journal:  Mol Cell Biol       Date:  1994-08       Impact factor: 4.272

5.  Interleukin 4 signals through two related pathways.

Authors:  A Pernis; B Witthuhn; A D Keegan; K Nelms; E Garfein; J N Ihle; W E Paul; J H Pierce; P Rothman
Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-15       Impact factor: 11.205

6.  Similarities and differences in signal transduction by interleukin 4 and interleukin 13: analysis of Janus kinase activation.

Authors:  A D Keegan; J A Johnston; P J Tortolani; L J McReynolds; C Kinzer; J J O'Shea; W E Paul
Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-15       Impact factor: 11.205

Review 7.  Janus kinases in immune cell signaling.

Authors:  Kamran Ghoreschi; Arian Laurence; John J O'Shea
Journal:  Immunol Rev       Date:  2009-03       Impact factor: 12.988

8.  Interleukin 7 independent development of human B cells.

Authors:  J A Prieyl; T W LeBien
Journal:  Proc Natl Acad Sci U S A       Date:  1996-09-17       Impact factor: 11.205

Review 9.  Exploring the Pathogenic Role and Therapeutic Implications of Interleukin 2 in Autoimmune Hepatitis.

Authors:  Albert J Czaja
Journal:  Dig Dis Sci       Date:  2020-08-24       Impact factor: 3.199

10.  The human T-cell leukemia/lymphotropic virus type 1 p12I proteins bind the interleukin-2 receptor beta and gammac chains and affects their expression on the cell surface.

Authors:  J C Mulloy; R W Crownley; J Fullen; W J Leonard; G Franchini
Journal:  J Virol       Date:  1996-06       Impact factor: 5.103
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