OBJECTIVE: To investigate the ability of gated methoxy-isobutylisonitrile (MIBI) scintigraphy to measure changes in myocardial function as well as perfusion with exercise. SETTING: Regional cardiothoracic centre. PATIENTS: 43 presenting with chest pain, 28 with coronary artery disease on angiography, and 15 with normal coronary arteriograms. RESULTS: Gated perfusion images showed an improvement in detecting regions with stenosed arteries compared with non-gated images (38/55 v 31/55, p < or = 0.01)). Functional analysis showed an increase in fractional shortening of 4.11% in subjects with normal coronary arteries, whereas in those with coronary disease a fall of 0.57% was found (p < or = 0.01). Both perfusion and function imaging showed an improved sensitivity compared with standard exercise testing (p < or = 0.01). When both function and perfusion imaging were analysed all patients with coronary disease were detected. There was agreement in abnormal regions in 33/55 territories supplied by a stenosed artery. Combined perfusion and function detected 49/55 (89%) of abnormal regions, thus improving the overall sensitivity from 38/55 (69%) by perfusion imaging alone (p < or = 0.01). CONCLUSIONS: Gated methoxy-isobutylisonitrile scintigraphy can successfully evaluate perfusion and function on exercise, so improving the diagnostic usefulness of this agent.
OBJECTIVE: To investigate the ability of gated methoxy-isobutylisonitrile (MIBI) scintigraphy to measure changes in myocardial function as well as perfusion with exercise. SETTING: Regional cardiothoracic centre. PATIENTS: 43 presenting with chest pain, 28 with coronary artery disease on angiography, and 15 with normal coronary arteriograms. RESULTS: Gated perfusion images showed an improvement in detecting regions with stenosed arteries compared with non-gated images (38/55 v 31/55, p < or = 0.01)). Functional analysis showed an increase in fractional shortening of 4.11% in subjects with normal coronary arteries, whereas in those with coronary disease a fall of 0.57% was found (p < or = 0.01). Both perfusion and function imaging showed an improved sensitivity compared with standard exercise testing (p < or = 0.01). When both function and perfusion imaging were analysed all patients with coronary disease were detected. There was agreement in abnormal regions in 33/55 territories supplied by a stenosed artery. Combined perfusion and function detected 49/55 (89%) of abnormal regions, thus improving the overall sensitivity from 38/55 (69%) by perfusion imaging alone (p < or = 0.01). CONCLUSIONS: Gated methoxy-isobutylisonitrile scintigraphy can successfully evaluate perfusion and function on exercise, so improving the diagnostic usefulness of this agent.
Authors: V Dilsizian; P Perrone-Filardi; R O Cannon; N M Freedman; S L Bacharach; R O Bonow Journal: Am J Cardiol Date: 1991-08-01 Impact factor: 2.778
Authors: P González; T Massardo; A Muñoz; J Jofré; A Rivera; J Yovanovich; E Maiers; F Ayala; P Humeres; A Ramírez; M Arriagada; A Zavala Journal: Eur J Nucl Med Date: 1996-10