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Literature DB >> 8036515

Preferential nucleosome assembly at DNA triplet repeats from the myotonic dystrophy gene.

Y H Wang¹, S Amirhaeri, S Kang, R D Wells, J D Griffith.

Abstract

The expansion of CTG repeats in DNA occurs in or near genes involved in several human diseases, including myotonic dystrophy and Huntington's disease. Nucleosomes, the basic structural element of chromosomes, consist of 146 base pairs of DNA coiled about an octamer of histone proteins and mediate general transcriptional repression. Electron microscopy was used to examine in vitro the nucleosome assembly of DNA containing repeating CTG triplets. The efficiency of nucleosome formation increased with expanded triplet blocks, suggesting that such blocks may repress transcription through the creation of stable nucleosomes.

Entities: Chemical Disease Species

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Year: 1994 PMID： 8036515 DOI： 10.1126/science.8036515

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

57 in total

1. Analysis of replication timing at the FRA10B and FRA16B fragile site loci.

Authors: O Handt; E Baker; S Dayan; S M Gartler; E Woollatt; R I Richards; R S Hansen
Journal: Chromosome Res Date: 2000 Impact factor: 5.239

Review 2. DNA secondary structure: a common and causative factor for expansion in human disease.

Authors: C T McMurray
Journal: Proc Natl Acad Sci U S A Date: 1999-03-02 Impact factor: 11.205

3. A mutation in a novel ATP-dependent Lon protease gene in a kindred with mild mental retardation.

Authors: Joseph J Higgins; Joanna Pucilowska; Roni Q Lombardi; John P Rooney
Journal: Neurology Date: 2004-11-23 Impact factor: 9.910

4. Transcriptional abnormality in myotonic dystrophy affects DMPK but not neighboring genes.

Authors: M G Hamshere; E E Newman; M Alwazzan; B S Athwal; J D Brook
Journal: Proc Natl Acad Sci U S A Date: 1997-07-08 Impact factor: 11.205

5. Expansion of a CUG trinucleotide repeat in the 3' untranslated region of myotonic dystrophy protein kinase transcripts results in nuclear retention of transcripts.

Authors: B M Davis; M E McCurrach; K L Taneja; R H Singer; D E Housman
Journal: Proc Natl Acad Sci U S A Date: 1997-07-08 Impact factor: 11.205

6. Nucleosomal occupancy and CGG repeat expansion: a comparative analysis of triplet repeat region from mouse and human fragile X mental retardation gene 1.

Authors: Sonal Datta; Mohammad Parwez Alam; Subeer S Majumdar; Abhishek Kumar Mehta; Souvik Maiti; Neerja Wadhwa; Vani Brahmachari
Journal: Chromosome Res Date: 2011-04-16 Impact factor: 5.239

Preferential nucleosome assembly at DNA triplet repeats from the myotonic dystrophy gene.

1. Analysis of replication timing at the FRA10B and FRA16B fragile site loci.

Review 2. DNA secondary structure: a common and causative factor for expansion in human disease.

3. A mutation in a novel ATP-dependent Lon protease gene in a kindred with mild mental retardation.

4. Transcriptional abnormality in myotonic dystrophy affects DMPK but not neighboring genes.

5. Expansion of a CUG trinucleotide repeat in the 3' untranslated region of myotonic dystrophy protein kinase transcripts results in nuclear retention of transcripts.

6. Nucleosomal occupancy and CGG repeat expansion: a comparative analysis of triplet repeat region from mouse and human fragile X mental retardation gene 1.

Review 7. Comparative genomics and molecular dynamics of DNA repeats in eukaryotes.

8. Regulation of V(D)J recombination by nucleosome positioning at recombination signal sequences.

Review 9. Myotonic dystrophy: clinical and molecular parallels between myotonic dystrophy type 1 and type 2.

Review 10. Misregulation of alternative splicing causes pathogenesis in myotonic dystrophy.