Literature DB >> 8036185

Elution characteristics of gentamicin-PMMA beads after implantation in humans.

C L Nelson1, S G Hickmon, B H Harrison.   

Abstract

Seventeen patients had gentamicin-PMMA beads implanted for treatment of orthopedic infections. The authors found that beads implanted in patients for 3 to 36 weeks were capable of eluting high levels of antibiotic after retrieval. Beads that were implanted in patients for less than 10 weeks eluted significantly higher antibiotic levels than beads were implanted for more than 14 weeks. This study supports the local use of these beads in the treatment of musculoskeletal infections.

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Year:  1994        PMID: 8036185     DOI: 10.3928/0147-7447-19940501-06

Source DB:  PubMed          Journal:  Orthopedics        ISSN: 0147-7447            Impact factor:   1.390


  10 in total

Review 1.  Nanostructured platforms for the sustained and local delivery of antibiotics in the treatment of osteomyelitis.

Authors:  Vuk Uskokovic
Journal:  Crit Rev Ther Drug Carrier Syst       Date:  2015       Impact factor: 4.889

Review 2.  The successful use of vancomycin-impregnated cement beads in a patient with vancomycin systemic toxicity: a case report with review of literature.

Authors:  V Mounasamy; P Fulco; P Desai; R Adelaar; G Bearman
Journal:  Eur J Orthop Surg Traumatol       Date:  2012-08-08

3.  Infected nonunions of long bones of the upper extremity: staged reconstruction using polymethylmethacrylate and bone graft impregnated with antibiotics.

Authors:  Christian Allende; Martin Mangupli; Julio Bagliardelli; Paula Diaz; Bartolome T Allende
Journal:  Chir Organi Mov       Date:  2009-10-30

Review 4.  Nanoparticulate drug delivery platforms for advancing bone infection therapies.

Authors:  Vuk Uskoković; Tejal A Desai
Journal:  Expert Opin Drug Deliv       Date:  2014-08-11       Impact factor: 6.648

5.  Self-defensive antimicrobial biomaterial surfaces.

Authors:  Xixi Xiao; Wenhan Zhao; Jing Liang; Karin Sauer; Matthew Libera
Journal:  Colloids Surf B Biointerfaces       Date:  2020-04-21       Impact factor: 5.268

6.  Permanent antibiotic impregnated intramedullary nail in diabetic limb salvage: a case report and literature review.

Authors:  Jason B Woods; Nicholas J Lowery; Patrick R Burns
Journal:  Diabet Foot Ankle       Date:  2012-02-01

7.  The effectiveness of antibiotic cement-coated nails in post-traumatic femoral and tibial osteomyelitis - comparative analysis of custom-made versus commercially available nails.

Authors:  Germán Garabano; Hernán Del Sel; Joaquin Anibal Rodriguez; Leonel Perez Alamino; Cesar Angel Pesciallo
Journal:  J Bone Jt Infect       Date:  2021-12-21

8.  Elution of gentamicin and vancomycin from polymethylmethacrylate beads and hip spacers in vivo.

Authors:  Konstantinos Anagnostakos; Philippe Wilmes; Eduard Schmitt; Jens Kelm
Journal:  Acta Orthop       Date:  2009-04       Impact factor: 3.717

9.  A new type of biphasic calcium phosphate cement as a gentamicin carrier for osteomyelitis.

Authors:  Wen-Yu Su; Yu-Chun Chen; Feng-Huei Lin
Journal:  Evid Based Complement Alternat Med       Date:  2013-04-09       Impact factor: 2.629

10.  Role of Antibiotic Cement Coated Nailing in Infected Nonunion of Tibia.

Authors:  C Bhatia; A K Tiwari; S B Sharma; S Thalanki; A Rai
Journal:  Malays Orthop J       Date:  2017-03
  10 in total

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