Literature DB >> 8035528

Analysis of integrated ground squirrel hepatitis virus and flanking host DNA in two hepatocellular carcinomas.

C Transy1, C A Renard, M A Buendia.   

Abstract

We cloned the integrated ground squirrel hepatitis B virus (GSHV) sequences from two hepatomas showing a single viral insertion. The GSHV inserts shared structural features with integrated DNAs of other hepadnaviruses. Insertional activation of a cellular gene appears unlikely: the integrated GSHV sequences lacked the known viral enhancers and were not expressed in the tumors, and we found no evidence for the presence of a gene at the integration site. Our results, together with those earlier studies, suggest that GSHV does not behave as an extensive insertional mutagen, in sharp contrast with the closely related woodchuck hepatitis virus. GSHV may thus cause carcinogenesis by more indirect mechanisms, as does the human hepatitis B virus.

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Year:  1994        PMID： 8035528      PMCID： PMC236477     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  26 in total

1.  Tight clustering of human hepatitis B virus integration sites in hepatomas near a triple-stranded region.

Authors:  C Shih; K Burke; M J Chou; J B Zeldis; C S Yang; C S Lee; K J Isselbacher; J R Wands; H M Goodman
Journal:  J Virol       Date:  1987-11       Impact factor: 5.103

Review 2.  The molecular biology of the hepatitis B viruses.

Authors:  D Ganem; H E Varmus
Journal:  Annu Rev Biochem       Date:  1987       Impact factor: 23.643

3.  Integration of hepatitis B virus DNA in chromosome-specific satellite sequences.

Authors:  Y Shaul; P D Garcia; S Schonberg; W J Rutter
Journal:  J Virol       Date:  1986-09       Impact factor: 5.103

4.  Genomic sequencing.

Authors:  G M Church; W Gilbert
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205

5.  Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma.

Authors:  A Dejean; L Bougueleret; K H Grzeschik; P Tiollais
Journal:  Nature       Date:  1986 Jul 3-9       Impact factor: 49.962

6.  Two additional potential retrotransposons isolated from a human L1 subfamily that contains an active retrotransposable element.

Authors:  B A Dombroski; A F Scott; H H Kazazian
Journal:  Proc Natl Acad Sci U S A       Date:  1993-07-15       Impact factor: 11.205

7.  Cloning and structural analysis of integrated woodchuck hepatitis virus sequences from hepatocellular carcinomas of woodchucks.

Authors:  C W Ogston; G J Jonak; C E Rogler; S M Astrin; J Summers
Journal:  Cell       Date:  1982-06       Impact factor: 41.582

8.  The genetic organization of integrated hepatitis B virus DNA in the human hepatoma cell line PLC/PRF/5.

Authors:  S Koch; A Freytag von Loringhoven; R Kahmann; P H Hofschneider; R Koshy
Journal:  Nucleic Acids Res       Date:  1984-09-11       Impact factor: 16.971

9.  Biochemical and genetic evidence for the hepatitis B virus replication strategy.

Authors:  C Seeger; D Ganem; H E Varmus
Journal:  Science       Date:  1986-04-25       Impact factor: 47.728

10.  A human hepatitis B viral enhancer element.

Authors:  Y Shaul; W J Rutter; O Laub
Journal:  EMBO J       Date:  1985-02       Impact factor: 11.598
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  1 in total

1.  Duck hepatitis B virus integrations in LMH chicken hepatoma cells: identification and characterization of new episomally derived integrations.

Authors:  S S Gong; A D Jensen; H Wang; C E Rogler
Journal:  J Virol       Date:  1995-12       Impact factor: 5.103
  1 in total

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