RATIONALE AND OBJECTIVES: The liver is the most common site for metastases from gastrointestinal tumors, malignant melanoma, and primary liver tumors. Early detection or exclusion of a neoplasm is important for appropriate treatment. The authors introduce a method for tumor transplantation into the rabbit liver for experimental purposes. METHODS: VX2 tumor cells initially were grown intraperitoneally in a New Zealand white rabbit. Using an automated biopsy instrument with an ultrathin-wall biopsy needle, standardized tumor samples were taken from the peritoneal tumor. Using the same technique, a tumor sample was transplanted into the left liver lobe in a series of seven rabbits. RESULTS: Tumor growth was achieved in all cases at the implantation site. The tumors were well delineated from the surrounding liver parenchyma. Metastases occurred only at later stages. CONCLUSION: The method is almost nontraumatic to the animals, and the technical procedure is simple, time-saving, and provides well-localized tumor growth.
RATIONALE AND OBJECTIVES: The liver is the most common site for metastases from gastrointestinal tumors, malignant melanoma, and primary liver tumors. Early detection or exclusion of a neoplasm is important for appropriate treatment. The authors introduce a method for tumor transplantation into the rabbit liver for experimental purposes. METHODS: VX2 tumor cells initially were grown intraperitoneally in a New Zealand white rabbit. Using an automated biopsy instrument with an ultrathin-wall biopsy needle, standardized tumor samples were taken from the peritoneal tumor. Using the same technique, a tumor sample was transplanted into the left liver lobe in a series of seven rabbits. RESULTS:Tumor growth was achieved in all cases at the implantation site. The tumors were well delineated from the surrounding liver parenchyma. Metastases occurred only at later stages. CONCLUSION: The method is almost nontraumatic to the animals, and the technical procedure is simple, time-saving, and provides well-localized tumor growth.
Authors: D Grönemeyer; R Seibel; R Erbel; A Schmidt; A Melzer; J Plassmann; M Deli; A Schmermund; D Baumgart; R Welsch; J Ge; G Goerge Journal: J Digit Imaging Date: 1996-05 Impact factor: 4.056
Authors: Sumeet Virmani; Kathleen R Harris; Barbara Szolc-Kowalska; Tatjana Paunesku; Gayle E Woloschak; Fred T Lee; Robert J Lewandowski; Kent T Sato; Robert K Ryu; Riad Salem; Andrew C Larson; Reed A Omary Journal: J Vasc Interv Radiol Date: 2008-04-18 Impact factor: 3.464
Authors: Sarah B White; Jeane Chen; Andrew C Gordon; Kathleen R Harris; Jodi R Nicolai; Derek L West; Andrew C Larson Journal: PLoS One Date: 2015-04-08 Impact factor: 3.240