Literature DB >> 8033973

Alteration of mitochondrial bioenergetics due to intravenous injection of a perfluorocarbon emulsion.

D Branca1, S M Chiarelli, E Vincenti, C Tortorella, G Scutari.   

Abstract

Wistar albino rats were intravenously injected with 1 ml of an oxyphoretic emulsion of perfluorobutyl-furane and killed 3, 7 or 30 days later. Mitochondria isolated from the liver and kidneys of treated rats showed a small decrease in the transmembrane electrical potential and a substantial depression of the rates of both ATP synthesis and ADP-stimulated respiration. These alterations in mitochondrial oxidative phosphorylation appear to be induced by perfluorocarbon and/or tensioactive molecules interacting with hydrophobic cell structures.

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Year:  1994        PMID： 8033973     DOI： 10.1007/bf01952868

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  18 in total

1.  Determination of serum proteins by means of the biuret reaction.

Authors:  A G GORNALL; C J BARDAWILL; M M DAVID
Journal:  J Biol Chem       Date:  1949-02       Impact factor: 5.157

2.  Interaction between erythrocytes and a perfluorochemical blood substitute.

Authors:  V V Tuliani; E A O'Rear; B M Fung; B D Sierra
Journal:  J Biomed Mater Res       Date:  1988-01

3.  Evaluation of some mitochondrial functions following liver perfusion with perfluorotributylamine emulsions.

Authors:  D Branca; G Scutari; N Siliprandi; E Vincenti; G Gambaretto
Journal:  Biochem Pharmacol       Date:  1988-06-15       Impact factor: 5.858

Review 4.  Physiological effects of perfluorocarbon blood substitutes.

Authors:  K C Lowe; A D Bollands
Journal:  Med Lab Sci       Date:  1985-10

5.  Fluosol 43 particle localization pattern in target organs of rats. An electron microscopy study.

Authors:  S Caiazza; C Fanizza; M Ferrari
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1984

6.  Studies on isolated rat liver perfused by perfluoro-compound emulsion.

Authors:  V Nováková; G Birke; L O Plantin; A Wretlind
Journal:  Fed Proc       Date:  1975-05

7.  Hemodynamic profile of adverse clinical reactions to Fluosol-DA 20%.

Authors:  K K Tremper; G M Vercellotti; D E Hammerschmidt
Journal:  Crit Care Med       Date:  1984-05       Impact factor: 7.598

8.  Activation of plasma complement by perfluorocarbon artificial blood: probable mechanism of adverse pulmonary reactions in treated patients and rationale for corticosteroids prophylaxis.

Authors:  G M Vercellotti; D E Hammerschmidt; P R Craddock; H S Jacob
Journal:  Blood       Date:  1982-06       Impact factor: 22.113

9.  [Function of the mononuclear phagocyte system after administration of emulsions of perfluorinated carbon compounds].

Authors:  F E Vishnevetskiĭ; A M Golubev; F F Beloiartsev; A E Vasil'ev; Iu E Pokrovskiĭ
Journal:  Biull Eksp Biol Med       Date:  1987-02

10.  Fluosol-DA as a red-cell substitute in acute anemia.

Authors:  S A Gould; A L Rosen; L R Sehgal; H L Sehgal; L A Langdale; L M Krause; C L Rice; W H Chamberlin; G S Moss
Journal:  N Engl J Med       Date:  1986-06-26       Impact factor: 91.245
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