Literature DB >> 8033086

Secretion of bioactive granulocyte-macrophage colony-stimulating factor by human colorectal carcinoma cells.

H Lahm1, J Wyniger, S Hertig, A Yilmaz, J R Fischer, J C Givel, N Odartchenko.   

Abstract

Secretion of several cytokines by colorectal carcinoma cells has been substantiated. These do not include granulocyte-macrophage colony-stimulating factor (GM-CSF) thus far. We show that the supernatant of two human colorectal carcinoma cell lines, LS1034 and SW480, stimulates proliferation of GM-CSF-dependent M07e cells. The activity was constitutively secreted by LS1034 cells and could be induced by serum-free culture conditions in SW480 cells. Addition of a neutralizing anti-GM-CSF antibody completely inhibited this activity. Preabsorption with anti-GM-CSF antibody removed all M07e growth-stimulating activity from LS1034 and SW480 supernatant. Western blot analysis revealed the presence of GM-CSF in LS1034 supernatant. Our results indicate that human colorectal carcinoma cells secrete indeed biologically active GM-CSF.

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Year:  1994        PMID： 8033086

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  8 in total

1.  Identification of a CD11b(+)/Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells.

Authors:  V Bronte; E Apolloni; A Cabrelle; R Ronca; P Serafini; P Zamboni; N P Restifo; P Zanovello
Journal:  Blood       Date:  2000-12-01       Impact factor: 22.113

Review 2.  The role of cytokines in pancreatic cancer.

Authors:  J Schmielau; H Kalthoff; C Roeder; W Schmiegel
Journal:  Int J Pancreatol       Date:  1996-06

3.  The host environment promotes the development of primary and metastatic squamous cell carcinomas that constitutively express proinflammatory cytokines IL-1alpha, IL-6, GM-CSF, and KC.

Authors:  C W Smith; Z Chen; G Dong; E Loukinova; M Y Pegram; L Nicholas-Figueroa; C Van Waes
Journal:  Clin Exp Metastasis       Date:  1998-10       Impact factor: 5.150

4.  Stem cell factor (SCF) and interleukin 3 (IL-3) in the sera of patients with colorectal cancer.

Authors:  Barbara Mroczko; Maciej Szmitkowski; Urszula Wereszczyńska-Siemiatkowska; Bogna Okulczyk
Journal:  Dig Dis Sci       Date:  2005-06       Impact factor: 3.199

5.  Tumor infiltration by FcγRIII (CD16)+ myeloid cells is associated with improved survival in patients with colorectal carcinoma.

Authors:  Giuseppe Sconocchia; Inti Zlobec; Alessandro Lugli; Diego Calabrese; Giandomenica Iezzi; Eva Karamitopoulou; Efstratios S Patsouris; George Peros; Milo Horcic; Luigi Tornillo; Markus Zuber; Raoul Droeser; Manuele G Muraro; Chantal Mengus; Daniel Oertli; Soldano Ferrone; Luigi Terracciano; Giulio C Spagnoli
Journal:  Int J Cancer       Date:  2010-10-13       Impact factor: 7.396

6.  Metastatic colorectal cancer cells induce matrix metalloproteinase release by human monocytes.

Authors:  C J Swallow; M P Murray; J G Guillem
Journal:  Clin Exp Metastasis       Date:  1996-01       Impact factor: 5.150

7.  Pretreatment serum levels of hematopoietic cytokines in patients with colorectal adenomas and cancer.

Authors:  Barbara Mroczko; Maciej Szmitkowski; Urszula Wereszczyńska-Siemiatkowska; Bogna Okulczyk; Bogusław Kedra
Journal:  Int J Colorectal Dis       Date:  2006-03-07       Impact factor: 2.571

8.  Granulocyte-colony stimulating factor producing rectal cancer.

Authors:  Hiroki Takahashi; Akira Yasuda; Nubuo Ochi; Masaki Sakamoto; Satoru Takayama; Takehiro Wakasugi; Hitoshi Funahashi; Hirozumi Sawai; Mikinori Satoh; Yoshimi Akamo; Hiromitsu Takeyama
Journal:  World J Surg Oncol       Date:  2008-06-29       Impact factor: 2.754
  8 in total

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