BACKGROUND AND AIM: Hematopoietic cytokines (HCs) regulate the proliferation and differentiation of hematopoietic progenitor cells, and it was proved that HCs can promote cancer growth. The aim of this study is to determine whether HCs might be useful in the diagnosis of colorectal cancer. MATERIALS AND METHODS: We compared the serum levels of stem cell factor (SCF), interleukin 3 (IL-3), granulocyte-macrophage colony-stimulating factor (GM-CSF), and macrophage colony-stimulating factor (M-CSF) in 97 colorectal cancer patients with those in 35 patients with colorectal adenomas and 65 healthy subjects (control group). Additionally, we investigated commonly accepted tumor markers, such as carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9). HCs were determined using enzyme linked immunosorbent assay (ELISA). CEA and CA 19-9 were measured by microparticle enzyme immunoassay. RESULTS: Serum levels of GM-CSF, M-CSF, and tumor markers were significantly higher in cancer patients as compared to the control group and adenomas patients. Of these, hematopoietic cytokines were found elevated in the higher proportion of patients than CEA and CA 19-9. The sensitivity of SCF was higher than the sensitivity of other cytokines, but diagnostic specificity and predictive value were highest for M-CSF. Moreover, the M-CSF area under the receiver operating characteristic curve was larger than the areas of other cytokines. The highest values of diagnostic parameters were observed for the combined use of M-CSF with CEA. CONCLUSION: The obtained data support the M-CSF usefulness as a tumor marker for colorectal cancer, especially in combination with CEA.
BACKGROUND AND AIM: Hematopoietic cytokines (HCs) regulate the proliferation and differentiation of hematopoietic progenitor cells, and it was proved that HCs can promote cancer growth. The aim of this study is to determine whether HCs might be useful in the diagnosis of colorectal cancer. MATERIALS AND METHODS: We compared the serum levels of stem cell factor (SCF), interleukin 3 (IL-3), granulocyte-macrophage colony-stimulating factor (GM-CSF), and macrophage colony-stimulating factor (M-CSF) in 97 colorectal cancerpatients with those in 35 patients with colorectal adenomas and 65 healthy subjects (control group). Additionally, we investigated commonly accepted tumor markers, such as carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9). HCs were determined using enzyme linked immunosorbent assay (ELISA). CEA and CA 19-9 were measured by microparticle enzyme immunoassay. RESULTS: Serum levels of GM-CSF, M-CSF, and tumor markers were significantly higher in cancerpatients as compared to the control group and adenomaspatients. Of these, hematopoietic cytokines were found elevated in the higher proportion of patients than CEA and CA 19-9. The sensitivity of SCF was higher than the sensitivity of other cytokines, but diagnostic specificity and predictive value were highest for M-CSF. Moreover, the M-CSF area under the receiver operating characteristic curve was larger than the areas of other cytokines. The highest values of diagnostic parameters were observed for the combined use of M-CSF with CEA. CONCLUSION: The obtained data support the M-CSF usefulness as a tumor marker for colorectal cancer, especially in combination with CEA.
Authors: M Trutmann; L Terracciano; C Noppen; J Kloth; M Kaspar; R Peterli; P Tondelli; C Schaeffer; P Zajac; M Heberer; G C Spagnoli Journal: Int J Cancer Date: 1998-07-29 Impact factor: 7.396
Authors: G Bobe; G Murphy; P S Albert; L B Sansbury; E Lanza; A Schatzkin; N H Colburn; A J Cross Journal: Br J Cancer Date: 2010-10-05 Impact factor: 7.640
Authors: Stefanie Bünger; Ulrike Haug; Maria Kelly; Nicole Posorski; Katja Klempt-Giessing; Andrew Cartwright; Stephen P Fitzgerald; Vicki Toner; Damien McAleer; Timo Gemoll; Tilman Laubert; Jürgen Büning; Klaus Fellermann; Hans-Peter Bruch; Uwe J Roblick; Hermann Brenner; Ferdinand von Eggeling; Jens K Habermann Journal: BMC Cancer Date: 2012-09-07 Impact factor: 4.430