Intergenic DNA and the sequence requirements for replication initiation in eukaryotes.

Replication in eukaryotes initiates at many origins per chromosome. The locations of most of these origins appear to be restricted to intergenic spacers. In this review, I propose that the sequence dependence of initiation seen in lower eukaryotes may be a by-product of the small size of intergenic sequences and may not reflect a general requirement of the mechanisms that control the initiation of replication.