OBJECTIVE: Low birth weight remains the leading cause of perinatal morbidity and mortality, but mechanisms mediating impaired fetal growth are poorly understood. To further define the role of abnormal immune activation and suppression in mediating impaired fetal growth, we measured levels of interleukin-10, a potent immunosuppressive cytokine not previously identified in association with pregnancy, in amniotic fluid samples obtained at genetic amniocentesis. STUDY DESIGN: In a case-control study with an enzyme-linked immunoassay we compared amniotic fluid levels of interleukin-10 in midtrimester samples obtained from appropriate-for-gestational age (n = 42) and small-for-gestational-age (n = 24) pregnancies. RESULTS: Interleukin-10 levels in small-for-gestational-age samples were elevated (median 78 pg/ml) compared with levels in control samples (median < 40 pg/ml), p = 0.02. In small-for-gestational-age pregnancies elevated levels were associated with nulliparity, p = 0.003. CONCLUSION: Our data support the role of abnormal immune activation, as opposed to inadequate immune suppression, in mediating impaired fetal growth.
OBJECTIVE: Low birth weight remains the leading cause of perinatal morbidity and mortality, but mechanisms mediating impaired fetal growth are poorly understood. To further define the role of abnormal immune activation and suppression in mediating impaired fetal growth, we measured levels of interleukin-10, a potent immunosuppressive cytokine not previously identified in association with pregnancy, in amniotic fluid samples obtained at genetic amniocentesis. STUDY DESIGN: In a case-control study with an enzyme-linked immunoassay we compared amniotic fluid levels of interleukin-10 in midtrimester samples obtained from appropriate-for-gestational age (n = 42) and small-for-gestational-age (n = 24) pregnancies. RESULTS:Interleukin-10 levels in small-for-gestational-age samples were elevated (median 78 pg/ml) compared with levels in control samples (median < 40 pg/ml), p = 0.02. In small-for-gestational-age pregnancies elevated levels were associated with nulliparity, p = 0.003. CONCLUSION: Our data support the role of abnormal immune activation, as opposed to inadequate immune suppression, in mediating impaired fetal growth.
Authors: Gila I Neta; Ondine S von Ehrenstein; Lynn R Goldman; Kirsten Lum; Rajeshwari Sundaram; William Andrews; Jun Zhang Journal: Am J Epidemiol Date: 2010-03-26 Impact factor: 4.897
Authors: Eric T Ricchetti; Sudheer C Reddy; Heather L Ansorge; Miltiadis H Zgonis; Jonathan P Van Kleunen; Kenneth W Liechty; Louis J Soslowsky; Pedro K Beredjiklian Journal: J Hand Surg Am Date: 2008-12 Impact factor: 2.230
Authors: Alice King; Swathi Balaji; Louis D Le; Emily Marsh; Timothy M Crombleholme; Sundeep G Keswani Journal: J Pediatr Surg Date: 2013-06 Impact factor: 2.545
Authors: Tobias Weissenbacher; Rüdiger P Laubender; Steven S Witkin; Andrea Gingelmaier; Barbara Schiessl; Franziskus Kainer; Klaus Friese; Udo Jeschke; Darius Dian; Katrin Karl Journal: BMC Res Notes Date: 2012-07-24
Authors: Carmen Elena Condrat; Valentin Nicolae Varlas; Florentina Duică; Panagiotis Antoniadis; Cezara Alina Danila; Dragos Cretoiu; Nicolae Suciu; Sanda Maria Crețoiu; Silviu Cristian Voinea Journal: Int J Mol Sci Date: 2021-04-09 Impact factor: 5.923
Authors: Christopher Schuster; Christine Vaculik; Christian Fiala; Simone Meindl; Oliver Brandt; Martin Imhof; Georg Stingl; Wolfgang Eppel; Adelheid Elbe-Bürger Journal: J Exp Med Date: 2009-01-12 Impact factor: 14.307