Literature DB >> 8029251

Biphasic effects of intraaccumbens mu-opioid peptide agonist DAMGO on locomotor activities.

M E Meyer1, B I McLaurin, M Allen, M E Meyer1.   

Abstract

The effects of bilateral microinjections of mu-opioid receptor agonist DAMGO (0.00, 0.01, 0.1, or 1.0 microgram/side) were tested in rats for 120 min in activity monitors. The horizontal movement, rearing, and stereotypy times in seconds were measured during 12 consecutive 10-min time blocks. DAMGO (0.01, 0.1, and 1.0 microgram) resulted in biphasic effects, inhibition followed by activation for each of the three measures. These data replicate the behavioral effects of ICV DAMGO except that the duration of the behavioral effects were longer with Acb injections.

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Year:  1994        PMID： 8029251     DOI： 10.1016/0091-3057(94)90283-6

Source DB:  PubMed          Journal:  Pharmacol Biochem Behav        ISSN： 0091-3057            Impact factor:   3.533


  6 in total

1.  Dual ultrastructural localization of mu-opioid receptors and NMDA-type glutamate receptors in the shell of the rat nucleus accumbens.

Authors:  K N Gracy; A L Svingos; V M Pickel
Journal:  J Neurosci       Date:  1997-06-15       Impact factor: 6.167

2.  mu-Opioid receptors are localized to extrasynaptic plasma membranes of GABAergic neurons and their targets in the rat nucleus accumbens.

Authors:  A L Svingos; A Moriwaki; J B Wang; G R Uhl; V M Pickel
Journal:  J Neurosci       Date:  1997-04-01       Impact factor: 6.167

3.  Cocaine and heroin ('speedball') self-administration: the involvement of nucleus accumbens dopamine and mu-opiate, but not delta-opiate receptors.

Authors:  Jennifer L Cornish; Jaclyn M Lontos; Kelly J Clemens; Iain S McGregor
Journal:  Psychopharmacology (Berl)       Date:  2005-01-29       Impact factor: 4.530

4.  Rats rapidly develop tolerance to the locomotor-inhibiting effects of the novel neuropeptide orphanin FQ.

Authors:  D P Devine; L Taylor; R K Reinscheid; F J Monsma; O Civelli; H Akil
Journal:  Neurochem Res       Date:  1996-11       Impact factor: 3.996

5.  Nucleus accumbens μ-opioid receptors mediate social reward.

Authors:  Viviana Trezza; Ruth Damsteegt; E J Marijke Achterberg; Louk J M J Vanderschuren
Journal:  J Neurosci       Date:  2011-04-27       Impact factor: 6.167

6.  Role of mu- and delta-opioid receptors in the nucleus accumbens in cocaine-seeking behavior.

Authors:  Diana Simmons; David W Self
Journal:  Neuropsychopharmacology       Date:  2009-03-11       Impact factor: 7.853
  6 in total

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