| Literature DB >> 8028444 |
P C Shaw1, W L Chan, H W Yeung, T B Ng.
Abstract
Trichosanthin (TCS), a protein isolated from the root tuber of the Chinese medicinal herb Trichosanthes kirilowii Maxim., is used to induce abortion in China. It also possesses immunomodulatory, anti-tumor and anti-human immunodeficiency virus properties. TCS is a member of the family of ribosome-inactivating proteins and inactivates eukaryotic ribosomes via its N-glycosidase activity. The gene encoding TCS has been cloned and over-expressed and the crystal structure of this protein resolved to 1.73A. In this review, the various pharmacological properties of TCS are discussed and assessed.Entities:
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Year: 1994 PMID： 8028444 DOI： 10.1016/0024-3205(94)00727-6
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037