Literature DB >> 8019109

Calcium-antagonist effect of quercetin and its relation with the spasmolytic properties of Psidium guajava L.

M A Morales1, J Tortoriello, M Meckes, D Paz, X Lozoya.   

Abstract

The antidiarrheal properties of water and methanolic extracts of Psidium guajava leaves have been demonstrated with anteriority and their spasmolytic effect was attributed to quercetin, a flavonoid contained in this plant. The present paper reports the intestinal smooth muscle relaxation produced by quercetin on isolated guinea pig ileum previously contracted by a depolarizing KCl solution. Quercetin also inhibited intestinal contraction induced by different concentrations of calcium, shifting the contraction curve to the right showing a clear calcium-antagonistic effect. Quercetin effect on ileal and aortic smooth muscles are compared, the ileum being more sensitive to this flavonoid. The calcium-antagonist property of quercetin is discussed and also its contribution to explain the spasmolytic effect of this popular herbal remedy.

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Year:  1994        PMID： 8019109

Source DB:  PubMed          Journal:  Arch Med Res        ISSN： 0188-4409            Impact factor:   2.235


  11 in total

1.  New benzophenone and quercetin galloyl glycosides from Psidium guajava L.

Authors:  Keiichi Matsuzaki; Rie Ishii; Kaori Kobiyama; Susumu Kitanaka
Journal:  J Nat Med       Date:  2010-03-31       Impact factor: 2.343

2.  Effects of two medicinal plants Psidium guajava L. (Myrtaceae) and Diospyros mespiliformis L. (Ebenaceae) leaf extracts on rat skeletal muscle cells in primary culture.

Authors:  R G Belemtougri; B Constantin; C Cognard; G Raymond; L Sawadogo
Journal:  J Zhejiang Univ Sci B       Date:  2006-01       Impact factor: 3.066

3.  Antispasmodic Effect of Blackcurrant (Ribes nigrum L.) Juice and Its Potential Use as Functional Food in Gastrointestinal Disorders.

Authors:  Bojana Miladinovic; Suzana Brankovic; Milica Kostic; Milica Milutinovic; Nemanja Kitic; Katarina Šavikin; Dušanka Kitic
Journal:  Med Princ Pract       Date:  2018-01-28       Impact factor: 1.927

4.  Guava extract (Psidium guajava) alters the labelling of blood constituents with technetium-99m.

Authors:  P R C Abreu; M C Almeida; R M Bernardo; L C Bernardo; L C Brito; E A C Garcia; A S Fonseca; M Bernardo-Filho
Journal:  J Zhejiang Univ Sci B       Date:  2006-06       Impact factor: 3.066

Review 5.  The Genus Alternanthera: Phytochemical and Ethnopharmacological Perspectives.

Authors:  Rajeev K Singla; Vivek Dhir; Reecha Madaan; Deepak Kumar; Simranjit Singh Bola; Monika Bansal; Suresh Kumar; Ankit Kumar Dubey; Shailja Singla; Bairong Shen
Journal:  Front Pharmacol       Date:  2022-04-11       Impact factor: 5.988

6.  Newer insights into the mechanism of action of Psidium guajava L. leaves in infectious diarrhoea.

Authors:  Tannaz Birdi; Poonam Daswani; S Brijesh; Pundarikakshudu Tetali; Arvind Natu; Noshir Antia
Journal:  BMC Complement Altern Med       Date:  2010-06-28       Impact factor: 3.659

7.  Sodium metabisulfite-induced polymerization of sickle cell hemoglobin incubated in the extracts of three medicinal plants (Anacardium occidentale, Psidium guajava, and Terminalia catappa).

Authors:  Paul Chidoka Chikezie
Journal:  Pharmacogn Mag       Date:  2011-04       Impact factor: 1.085

8.  Antiprotozoal Constituents from Annona cherimola Miller, a Plant Used in Mexican Traditional Medicine for the Treatment of Diarrhea and Dysentery.

Authors:  Fernando Calzada; Jose Correa-Basurto; Elizabeth Barbosa; David Mendez-Luna; Lilian Yepez-Mulia
Journal:  Pharmacogn Mag       Date:  2017 Jan-Mar       Impact factor: 1.085

9.  Antimicrobial Activities of Leaf Extracts of Guava (Psidium guajava L.) on Two Gram-Negative and Gram-Positive Bacteria.

Authors:  Bipul Biswas; Kimberly Rogers; Fredrick McLaughlin; Dwayne Daniels; Anand Yadav
Journal:  Int J Microbiol       Date:  2013-10-20

10.  In Vitro Impact of Hydro-alcoholic Extract of Rosa damascena Mill. on Rat Ileum Contractions and the Mechanisms Involved.

Authors:  Mehrnoosh Sedighi; Mahmoud Rafieian-Kopaei; Mosayeb Noori-Ahmadabadi; Iraj Godarzi; Azar Baradaran
Journal:  Int J Prev Med       Date:  2014-06
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