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Literature DB >> 8018534

Deletion analysis of chromosome 8p in sporadic colorectal adenomas.

C Cunningham¹, M G Dunlop, C C Bird, A H Wyllie.

Abstract

In order to assess the stage of colorectal tumorigenesis at which chromosome 8p loss of heterozygosity (LOH) occurs, 56 sporadic adenomas were examined for LOH at four polymorphic loci which show frequent LOH in carcinomas. LOH was found in only 5 out of 51 (9.8%) informative adenomas, whereas studies with the same markers in 85 informative carcinomas showed a LOH of 45%. The adenomas showing LOH were all in the 'high-risk' clinicopathological category, being 10 mm or more in diameter and showing tubulovillous architecture. It is concluded that the chromosome 8p locus is involved preferentially in the development of carcinomas rather than adenomas.

Entities: Disease

Mesh：

Year: 1994 PMID： 8018534 PMCID： PMC2033333 DOI： 10.1038/bjc.1994.243

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

22 in total

1. Allelic loss at chromosome band 8p21.3-p22 is associated with progression of hepatocellular carcinoma.

Authors: M Emi; Y Fujiwara; H Ohata; H Tsuda; S Hirohashi; M Koike; M Miyaki; M Monden; Y Nakamura
Journal: Genes Chromosomes Cancer Date: 1993-07 Impact factor: 5.006

2. Microsatellite instability in cancer of the proximal colon.

Authors: S N Thibodeau; G Bren; D Schaid
Journal: Science Date: 1993-05-07 Impact factor: 47.728

3. Clues to the pathogenesis of familial colorectal cancer.

Authors: L A Aaltonen; P Peltomäki; F S Leach; P Sistonen; L Pylkkänen; J P Mecklin; H Järvinen; S M Powell; J Jen; S R Hamilton
Journal: Science Date: 1993-05-07 Impact factor: 47.728

4. Frequent loss of heterozygosity for loci on chromosome 8p in hepatocellular carcinoma, colorectal cancer, and lung cancer.

Authors: M Emi; Y Fujiwara; T Nakajima; E Tsuchiya; H Tsuda; S Hirohashi; Y Maeda; K Tsuruta; M Miyaki; Y Nakamura
Journal: Cancer Res Date: 1992-10-01 Impact factor: 12.701

5. APC mutations occur early during colorectal tumorigenesis.

Authors: S M Powell; N Zilz; Y Beazer-Barclay; T M Bryan; S R Hamilton; S N Thibodeau; B Vogelstein; K W Kinzler
Journal: Nature Date: 1992-09-17 Impact factor: 49.962

6. Deletion mapping of chromosome 8 in cancers of the urinary bladder using restriction fragment length polymorphisms and microsatellite polymorphisms.

Authors: M A Knowles; M E Shaw; A J Proctor
Journal: Oncogene Date: 1993-05 Impact factor: 9.867

Deletion analysis of chromosome 8p in sporadic colorectal adenomas.

1. Allelic loss at chromosome band 8p21.3-p22 is associated with progression of hepatocellular carcinoma.

2. Microsatellite instability in cancer of the proximal colon.

3. Clues to the pathogenesis of familial colorectal cancer.

4. Frequent loss of heterozygosity for loci on chromosome 8p in hepatocellular carcinoma, colorectal cancer, and lung cancer.

5. APC mutations occur early during colorectal tumorigenesis.

6. Deletion mapping of chromosome 8 in cancers of the urinary bladder using restriction fragment length polymorphisms and microsatellite polymorphisms.

7. Evidence for the presence of two tumor suppressor genes on chromosome 8p for colorectal carcinoma.

8. Deletion mapping in colorectal cancer of a putative tumour suppressor gene in 8p22-p21.3.

9. Stabilised p53 facilitates aneuploid clonal divergence in colorectal cancer.

10. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis.

1. Loss of heterozygosity and microsatellite instability in de novo versus ex-adenoma carcinomas of the colorectum.

2. Allelic imbalance of 8p indicates poor survival in gastric cancer.