Literature DB >> 8014102

Close correlation between the dephosphorylation of p53 and growth suppression by transforming growth factor-beta 1 in nasopharyngeal carcinoma cells transduced with adenovirus early region genes.

Y Mogi1, J Kato, M Horimoto, R Takimoto, T Murakami, A Hirayama, Y Kohgo, N Watanabe, Y Niitsu.   

Abstract

The mechanism of growth inhibition by transforming growth factor (TGF)-beta 1 was investigated. We examined the growth inhibitory effects of TGF-beta 1 on human nasopharyngeal carcinoma (KB) cells which constitutively expressed p53. TGF-beta 1 suppressed the DNA synthesis of KB cells in a dose-dependent manner. It had minimal effect on adenovirus-2-transduced KB cells expressing either adenovirus early region 1B (E1B) or 1A (E1A) product, which respectively binds to p53 or Rb product and inhibits its function, and no growth inhibition at all was observed with KB cells expressing both E1B and E1A products. Dephosphorylation of the p53 was promoted by TGF-beta 1 stimulation in KB cells, but not in E1B-producing KB cells, which sequestrate the function of p53. The growth inhibition of KB cells by TGF-beta 1 was significantly reduced by treatment with okadaic acid. These results suggest that p53 transduces the antiproliferative signal of TGF-beta 1 possibly through its dephosphorylation.

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Year:  1994        PMID： 8014102      PMCID： PMC5919502          DOI： 10.1111/j.1349-7006.1994.tb02380.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  29 in total

1.  Inhibition of DNA synthesis by TGF-beta 1 coincides with inhibition of phosphorylation and cytoplasmic translocation of p53 protein.

Authors:  K Suzuki; T Ono; K Takahashi
Journal:  Biochem Biophys Res Commun       Date:  1992-03-31       Impact factor: 3.575

2.  Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.

Authors:  J Martinez; I Georgoff; J Martinez; A J Levine
Journal:  Genes Dev       Date:  1991-02       Impact factor: 11.361

3.  TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains.

Authors:  J A Pietenpol; R W Stein; E Moran; P Yaciuk; R Schlegel; R M Lyons; M R Pittelkow; K Münger; P M Howley; H L Moses
Journal:  Cell       Date:  1990-06-01       Impact factor: 41.582

4.  WAF1, a potential mediator of p53 tumor suppression.

Authors:  W S el-Deiry; T Tokino; V E Velculescu; D B Levy; R Parsons; J M Trent; D Lin; W E Mercer; K W Kinzler; B Vogelstein
Journal:  Cell       Date:  1993-11-19       Impact factor: 41.582

5.  Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells.

Authors:  P Sarnow; Y S Ho; J Williams; A J Levine
Journal:  Cell       Date:  1982-02       Impact factor: 41.582

6.  Temperature-dependent switching between "wild-type" and "mutant" forms of p53-Val135.

Authors:  J Milner; E A Medcalf
Journal:  J Mol Biol       Date:  1990-12-05       Impact factor: 5.469

7.  Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2.

Authors:  J R Bischoff; P N Friedman; D R Marshak; C Prives; D Beach
Journal:  Proc Natl Acad Sci U S A       Date:  1990-06       Impact factor: 11.205

8.  Wild-type p53 can down-modulate the activity of various promoters.

Authors:  D Ginsberg; F Mechta; M Yaniv; M Oren
Journal:  Proc Natl Acad Sci U S A       Date:  1991-11-15       Impact factor: 11.205

9.  Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors.

Authors:  R Derynck; D V Goeddel; A Ullrich; J U Gutterman; R D Williams; T S Bringman; W H Berger
Journal:  Cancer Res       Date:  1987-02-01       Impact factor: 12.701

10.  Suppression of the EGF-dependent induction of c-myc proto-oncogene expression by transforming growth factor beta in a human breast carcinoma cell line.

Authors:  J A Fernandez-Pol; V D Talkad; D J Klos; P D Hamilton
Journal:  Biochem Biophys Res Commun       Date:  1987-05-14       Impact factor: 3.575
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  3 in total

1.  Candidate pathways and genes for nasopharyngeal carcinoma based on bioinformatics study.

Authors:  Jinhui Chen; Rui Yang; Wei Zhang; Yongping Wang
Journal:  Int J Clin Exp Pathol       Date:  2015-02-01

2.  Wild-type p53 gene-induced morphological changes and growth suppression in hepatoma cells.

Authors:  S Terai; T Noma; T Kimura; A Nakazawa; F Kurokawa; K Okita
Journal:  J Gastroenterol       Date:  1997-06       Impact factor: 7.527

3.  Inhibition of p53 protein phosphorylation by 9-hydroxyellipticine: a possible anticancer mechanism.

Authors:  M Ohashi; E Sugikawa; N Nakanishi
Journal:  Jpn J Cancer Res       Date:  1995-09
  3 in total

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