Literature DB >> 8013428

Using cell replication data in mathematical modeling in carcinogenesis.

C J Portier1, A Kopp-Schneider, C D Sherman.   

Abstract

Risk estimation involves the application of quantitative models of dose versus response to carcinogenicity data. Recent advances in biology, computing, and mathematics have led to the application of mathematically complicated, mechanistically based models of carcinogenesis to the estimation of risks. This paper focuses on two aspects of this application, distinguishing between models using available data and the development of new models to keep pace with research developments.

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Year:  1993        PMID： 8013428      PMCID： PMC1519438          DOI： 10.1289/ehp.93101s579

Source DB:  PubMed          Journal:  Environ Health Perspect        ISSN： 0091-6765            Impact factor:   9.031


  28 in total

1.  Uncertainty estimates for low-dose-rate extrapolations of animal carcinogenicity data.

Authors:  H Guess; K Crump; R Peto
Journal:  Cancer Res       Date:  1977-10       Impact factor: 12.701

2.  A note on approximating the cumulative distribution function of the time to tumor onset in multistage models.

Authors:  A Kopp; C J Portier
Journal:  Biometrics       Date:  1989-12       Impact factor: 2.571

3.  Two-stage model for carcinogenesis: Epidemiology of breast cancer in females.

Authors:  S H Moolgavkar; N E Day; R G Stevens
Journal:  J Natl Cancer Inst       Date:  1980-09       Impact factor: 13.506

4.  Variability of safe dose estimates when using complicated models of the carcinogenic process. A case study: methylene chloride.

Authors:  C J Portier; N L Kaplan
Journal:  Fundam Appl Toxicol       Date:  1989-10

5.  Two-stage models of tumor incidence for historical control animals in the National Toxicology Program's carcinogenicity experiments.

Authors:  C J Portier; A J Bailer
Journal:  J Toxicol Environ Health       Date:  1989

6.  Multistage models and primary prevention of cancer.

Authors:  N E Day; C C Brown
Journal:  J Natl Cancer Inst       Date:  1980-04       Impact factor: 13.506

7.  A multistage model of carcinogenesis incorporating DNA damage and repair.

Authors:  C J Portier; A Kopp-Schneider
Journal:  Risk Anal       Date:  1991-09       Impact factor: 4.000

8.  Statistical properties of a two-stage model of carcinogenesis.

Authors:  C J Portier
Journal:  Environ Health Perspect       Date:  1987-12       Impact factor: 9.031

9.  A novel combination of K-ras and myc amplification accompanied by point mutational activation of K-ras in a human lung cancer.

Authors:  Y Taya; K Hosogai; S Hirohashi; Y Shimosato; R Tsuchiya; N Tsuchida; M Fushimi; T Sekiya; S Nishimura
Journal:  EMBO J       Date:  1984-12-01       Impact factor: 11.598

10.  A two-stage theory of carcinogenesis in relation to the age distribution of human cancer.

Authors:  P ARMITAGE; R DOLL
Journal:  Br J Cancer       Date:  1957-06       Impact factor: 7.640
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  1 in total

Review 1.  Cell proliferation and chemical carcinogenesis: symposium overview.

Authors:  R L Melnick; J Huff; J C Barrett; R R Maronpot; G Lucier; C J Portier
Journal:  Environ Health Perspect       Date:  1993-12       Impact factor: 9.031
  1 in total

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