Literature DB >> 8003971

Acid sphingomyelinase possesses a domain homologous to its activator proteins: saposins B and D.

C P Ponting1.   

Abstract

An N-terminal region of the acid sphingomyelinase sequence (residues 89-165) is shown to be homologous to saposin-type sequences. By analogy with the known functions of saposins, this sphingomyelinase saposin-type domain may possess lipid-binding and/or sphingomyelinase-activator properties. This finding may prove to be important in the understanding of Niemann-Pick disease, which results from sphingomyelinase deficiency.

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Year:  1994        PMID： 8003971      PMCID： PMC2142785          DOI： 10.1002/pro.5560030219

Source DB:  PubMed          Journal:  Protein Sci        ISSN： 0961-8368            Impact factor:   6.725


  25 in total

1.  Characterization of a nonspecific activator protein for the enzymatic hydrolysis of glycolipids.

Authors:  S C Li; S Sonnino; G Tettamanti; Y T Li
Journal:  J Biol Chem       Date:  1988-05-15       Impact factor: 5.157

2.  Saposin D: a sphingomyelinase activator.

Authors:  S Morimoto; B M Martin; Y Kishimoto; J S O'Brien
Journal:  Biochem Biophys Res Commun       Date:  1988-10-14       Impact factor: 3.575

3.  Protein multiple sequence alignment and flexible pattern matching.

Authors:  G J Barton
Journal:  Methods Enzymol       Date:  1990       Impact factor: 1.600

4.  Saposin A: second cerebrosidase activator protein.

Authors:  S Morimoto; B M Martin; Y Yamamoto; K A Kretz; J S O'Brien; Y Kishimoto
Journal:  Proc Natl Acad Sci U S A       Date:  1989-05       Impact factor: 11.205

5.  Insertion in the mRNA of a metachromatic leukodystrophy patient with sphingolipid activator protein-1 deficiency.

Authors:  X L Zhang; M A Rafi; G DeGala; D A Wenger
Journal:  Proc Natl Acad Sci U S A       Date:  1990-02       Impact factor: 11.205

6.  Cloning of a human acid sphingomyelinase cDNA with a new mutation that renders the enzyme inactive.

Authors:  H Ida; O M Rennert; Y Eto; W Y Chan
Journal:  J Biochem       Date:  1993-07       Impact factor: 3.387

7.  Coding of two sphingolipid activator proteins (SAP-1 and SAP-2) by same genetic locus.

Authors:  J S O'Brien; K A Kretz; N Dewji; D A Wenger; F Esch; A L Fluharty
Journal:  Science       Date:  1988-08-26       Impact factor: 47.728

8.  Interaction of saposins, acidic lipids, and glucosylceramidase.

Authors:  S Morimoto; Y Kishimoto; J Tomich; S Weiler; T Ohashi; J A Barranger; K A Kretz; J S O'Brien
Journal:  J Biol Chem       Date:  1990-02-05       Impact factor: 5.157

9.  Structure and organization of the gene encoding human pulmonary surfactant proteolipid SP-B.

Authors:  T J Pilot-Matias; S E Kister; J L Fox; K Kropp; S W Glasser; J A Whitsett
Journal:  DNA       Date:  1989-03

10.  An ion-channel forming protein produced by Entamoeba histolytica.

Authors:  E C Lynch; I M Rosenberg; C Gitler
Journal:  EMBO J       Date:  1982       Impact factor: 11.598
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  10 in total

Review 1.  A short guided tour through functional and structural features of saposin-like proteins.

Authors:  Heike Bruhn
Journal:  Biochem J       Date:  2005-07-15       Impact factor: 3.857

2.  J3-crystallin of the jellyfish lens: similarity to saposins.

Authors:  J Piatigorsky; B Norman; L J Dishaw; L Kos; J Horwitz; P J Steinbach; Z Kozmik
Journal:  Proc Natl Acad Sci U S A       Date:  2001-10-23       Impact factor: 11.205

3.  A model of the acid sphingomyelinase phosphoesterase domain based on its remote structural homolog purple acid phosphatase.

Authors:  Marian Seto; Marc Whitlow; Margaret A McCarrick; Subha Srinivasan; Ying Zhu; Rene Pagila; Robert Mintzer; David Light; Anthony Johns; Janet A Meurer-Ogden
Journal:  Protein Sci       Date:  2004-12       Impact factor: 6.725

Review 4.  Saposins and their interaction with lipids.

Authors:  A M Vaccaro; R Salvioli; M Tatti; F Ciaffoni
Journal:  Neurochem Res       Date:  1999-02       Impact factor: 3.996

Review 5.  Roles and regulation of secretory and lysosomal acid sphingomyelinase.

Authors:  Russell W Jenkins; Daniel Canals; Yusuf A Hannun
Journal:  Cell Signal       Date:  2009-06       Impact factor: 4.315

6.  Sphingomyelin phosphodiesterase acid-like 3A (SMPDL3A) is a novel nucleotide phosphodiesterase regulated by cholesterol in human macrophages.

Authors:  Mathew Traini; Carmel M Quinn; Cecilia Sandoval; Erik Johansson; Kate Schroder; Maaike Kockx; Peter J Meikle; Wendy Jessup; Leonard Kritharides
Journal:  J Biol Chem       Date:  2014-10-06       Impact factor: 5.157

7.  Acid sphingomyelinase activity is regulated by membrane lipids and facilitates cholesterol transfer by NPC2.

Authors:  Vincent O Oninla; Bernadette Breiden; Jonathan O Babalola; Konrad Sandhoff
Journal:  J Lipid Res       Date:  2014-10-22       Impact factor: 5.922

8.  Antiviral Activity of a Turbot (Scophthalmus maximus) NK-Lysin Peptide by Inhibition of Low-pH Virus-Induced Membrane Fusion.

Authors:  Alberto Falco; Regla María Medina-Gali; José Antonio Poveda; Melissa Bello-Perez; Beatriz Novoa; José Antonio Encinar
Journal:  Mar Drugs       Date:  2019-02-01       Impact factor: 5.118

Review 9.  Acid Sphingomyelinase Deficiency: A Clinical and Immunological Perspective.

Authors:  Carolina Pinto; Diana Sousa; Vladimir Ghilas; Andrea Dardis; Maurizio Scarpa; Maria Fatima Macedo
Journal:  Int J Mol Sci       Date:  2021-11-28       Impact factor: 5.923

10.  Characterization of Sphingomyelin Phosphodiesterase Expression in Bumblebee (Bombus lantschouensis).

Authors:  Lei Han; Guiling Ding; Yanjie Liu; Jiaxing Huang; Jie Wu
Journal:  J Insect Sci       Date:  2018-09-01       Impact factor: 1.857
  10 in total

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