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Literature DB >> 7998828

Porphyrin studies in TCDD-exposed workers.

D Jung¹, J Konietzko, G Reill-Konietzko, A Muttray, H J Zimmermann-Hölz, M Doss, H Beck, L Edler, A Kopp-Schneider.

Abstract

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has been shown to inhibit uroporphyrinogen decarboxylase activity resulting in chronic hepatic porphyria. From a cross-sectional study of 170 workers in chemical industry 68 showed elevated coproporphyrin levels, interpreted as secondary coproporphyrinuria. Three persons suffered from chronic hepatic porphyria in subclinical stages. None of the workers showed an overt porphyria cutanea tarda. A low-grade zinc protoporphyrinemia was observed in three persons. Forty-three of the 170 workers were evaluable for investigating the effect of TCDD on porphyrin levels. No significant correlation was found between TCDD concentration in adipose tissue and the level of uroporphyrin and coproporphyrin. The influence of a chloracne history is described.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1994 PMID： 7998828 DOI： 10.1007/s002040050120

Source DB: PubMed Journal: Arch Toxicol ISSN： 0340-5761 Impact factor: 5.153

16 in total

1. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced porphyria in genetically inbred mice: partial antagonism and mechanistic studies.

Authors: C Yao; S Safe
Journal: Toxicol Appl Pharmacol Date: 1989-09-01 Impact factor: 4.219

2. Analytical and preparative thin-layer chromatography of porphyrin methyl esters.

Authors: M Doss
Journal: Z Klin Chem Klin Biochem Date: 1970-05

3. Leads from the MMWR. Porphyria cutanea tarda and sarcoma in a worker exposed to 2,3,7,8-tetrachlorodibenzodioxin-Missouri.

Authors:
Journal: JAMA Date: 1984 Mar 23-30 Impact factor: 56.272

4. Medical evaluation of subjects with known body levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Authors: K B Webb; R G Evans; A P Knutsen; S T Roodman; D W Roberts; W F Schramm; B B Gibson; J S Andrews; L L Needham; D G Patterson
Journal: J Toxicol Environ Health Date: 1989

5. Development of chronic hepatic porphyria (porphyria cutanea tarda) with inherited uroporphyrinogen decarboxylase deficiency under exposure to dioxin.

Authors: M Doss; H Sauer; R von Tiepermann; A M Colombi
Journal: Int J Biochem Date: 1984

6. Induction of porphyria in the rat by chronic versus acute exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Authors: J A Goldstein; P Linko; H Bergman
Journal: Biochem Pharmacol Date: 1982-04-15 Impact factor: 5.858

7. Continued depression of hepatic uroporphyrinogen decarboxylase activity caused by hexachlorobenzene or 2,3,7,8-tetrachlorodibenzo-p-dioxin despite regeneration after partial hepatectomy.

Authors: A G Smith; J E Francis; J B Greig
Journal: Biochem Pharmacol Date: 1985-05-15 Impact factor: 5.858

8. The development and prognosis of chronic intoxication by tetrachlordibenzo-p-dioxin in men.

Authors: J Pazderova-Vejlupková; E Lukás; M Nĕmcova; J Pícková; L Jirásek
Journal: Arch Environ Health Date: 1981 Jan-Feb

9. A pilot epidemiologic study of possible health effects associated with 2,3,7,8-tetrachlorodibenzo-p-dioxin contaminations in Missouri.

Authors: P A Stehr; G Stein; K Webb; W Schramm; W B Gedney; H D Donnell; S Ayres; H Falk; E Sampson; S J Smith
Journal: Arch Environ Health Date: 1986 Jan-Feb

Porphyrin studies in TCDD-exposed workers.

1. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced porphyria in genetically inbred mice: partial antagonism and mechanistic studies.

2. Analytical and preparative thin-layer chromatography of porphyrin methyl esters.

3. Leads from the MMWR. Porphyria cutanea tarda and sarcoma in a worker exposed to 2,3,7,8-tetrachlorodibenzodioxin-Missouri.

4. Medical evaluation of subjects with known body levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin.

5. Development of chronic hepatic porphyria (porphyria cutanea tarda) with inherited uroporphyrinogen decarboxylase deficiency under exposure to dioxin.

6. Induction of porphyria in the rat by chronic versus acute exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

7. Continued depression of hepatic uroporphyrinogen decarboxylase activity caused by hexachlorobenzene or 2,3,7,8-tetrachlorodibenzo-p-dioxin despite regeneration after partial hepatectomy.

8. The development and prognosis of chronic intoxication by tetrachlordibenzo-p-dioxin in men.

9. A pilot epidemiologic study of possible health effects associated with 2,3,7,8-tetrachlorodibenzo-p-dioxin contaminations in Missouri.

10. [Chloracne, porphyria cutanea tarda, and other poisonings due to the herbicides].

Review 1. Porphyrias in Japan: compilation of all cases reported through 2002.

2. Biomarker measurements in a coastal fish-eating population environmentally exposed to organochlorines.

3. Serum organochlorines and urinary porphyrin pattern in a population highly exposed to hexachlorobenzene.

Review 4. Aryl Hydrocarbon Receptor and Dioxin-Related Health Hazards-Lessons from Yusho.