Literature DB >> 7996379

The power-consumption-controlled extruder: a tool for pellet production.

P Kleinebudde1, A J Sølvberg, H Lindner.   

Abstract

Based on the assumption that there is a link between power consumption of an extruder and pellet properties, a control circuit for power consumption was developed. Powder and granulation liquid are fed separately into a twin-screw extruder. The power consumption is controlled by varying the pump rate at a given powder-feed rate; consequently each level of power consumption results in a specific water content of the extrudate for a particular formulation. The shape of pellets depends almost entirely on the level of power consumption irrespective of formulation. The size of dry pellets is additionally affected by a shrinking factor which depends on the water content. The power-consumption-controlled extruder is an appropriate tool for the production of pellets. The system is able to adapt the water content for a formulation automatically.

Entities:  

Mesh:

Substances:

Year:  1994        PMID: 7996379     DOI: 10.1111/j.2042-7158.1994.tb03853.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN: 0022-3573            Impact factor:   3.765


  6 in total

Review 1.  Microcrystalline cellulose as a sponge as an alternative concept to the crystallite-gel model for extrusion and spheronization.

Authors:  R Ek; J M Newton
Journal:  Pharm Res       Date:  1998-04       Impact factor: 4.200

2.  Influence of the degree of polymerization on the behavior of cellulose during homogenization and extrusion/spheronization.

Authors:  P Kleinebudde; M Jumaa; F El Saleh
Journal:  AAPS PharmSci       Date:  2000

3.  Direct pelletization in a rotary processor controlled by torque measurements. II: effects of changes in the content of microcrystalline cellulose.

Authors:  J Kristensen; T Schaefer; P Kleinebudde
Journal:  AAPS PharmSci       Date:  2000

4.  The crystallite-gel-model for microcrystalline cellulose in wet-granulation, extrusion, and spheronization.

Authors:  P Kleinebudde
Journal:  Pharm Res       Date:  1997-06       Impact factor: 4.200

5.  Structure of disintegrating pellets with regard to fractal geometry.

Authors:  M Schröder; P Kleinebudde
Journal:  Pharm Res       Date:  1995-11       Impact factor: 4.200

Review 6.  Advances in Twin-Screw Granulation Processing.

Authors:  Uttom Nandi; Vivek Trivedi; Steven A Ross; Dennis Douroumis
Journal:  Pharmaceutics       Date:  2021-04-27       Impact factor: 6.321

  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.