Literature DB >> 7993370

Biochemical genetics of methylglyoxal dehydrogenases in the laboratory rat (Rattus norvegicus).

K Bender1, R T Seibert, T F Wienker, V Kren, M Pravenec, S Bissbort.   

Abstract

A genetic locus controlling the electrophoretic mobility of a methylglyoxal dehydrogenase (EC 1.2.1.23) in the rat is described. The locus, designated Mgd1, is expressed in liver and kidney. Inbred rat strains have fixed either allele Mgd1a or allele Mgd1b. Codominant expression is observed in heterozygotes, providing evidence for a tetrameric enzyme structure. Backcross progenies showed the expected 1:1 segregation ratio, and there is evidence that Mgd1 is linked to Pep3 and Fh1 on chromosome 13. There is also evidence for two additional methylglyoxal dehydrogenases: Mgd2, present in liver and kidney, and Mgd3, present only in heart.

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Year:  1994        PMID： 7993370     DOI： 10.1007/BF00554618

Source DB:  PubMed          Journal:  Biochem Genet        ISSN： 0006-2928            Impact factor:   1.890


  12 in total

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Journal:  Genetics       Date:  1931-07       Impact factor: 4.562

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Journal:  J Biol Chem       Date:  1967-10-25       Impact factor: 5.157

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Authors:  J P Richard
Journal:  Biochem Soc Trans       Date:  1993-05       Impact factor: 5.407

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Journal:  J Biol Chem       Date:  1981-06-25       Impact factor: 5.157

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Journal:  Mol Biochem Parasitol       Date:  1989-06-01       Impact factor: 1.759

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Journal:  Genomics       Date:  1991-07       Impact factor: 5.736

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Journal:  J Biol Chem       Date:  1982-09-25       Impact factor: 5.157

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  3 in total

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2.  A genetic linkage map of the rat derived from recombinant inbred strains.

Authors:  M Pravenec; D Gauguier; J J Schott; J Buard; V Kren; V Bílá; C Szpirer; J Szpirer; J M Wang; H Huang; E St Lezin; M A Spence; P Flodman; M Printz; G M Lathrop; G Vergnaud; T W Kurtz
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  3 in total

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