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Literature DB >> 8835528

A genetic linkage map of the rat derived from recombinant inbred strains.

M Pravenec¹, D Gauguier, J J Schott, J Buard, V Kren, V Bílá, C Szpirer, J Szpirer, J M Wang, H Huang, E St Lezin, M A Spence, P Flodman, M Printz, G M Lathrop, G Vergnaud, T W Kurtz.

Abstract

We have constructed a genetic linkage map in the rat by analyzing the strain distribution patterns of 500 genetic markers in a large set of recombinant inbred strains derived from the spontaneously hypertensive rat and the Brown-Norway rat (HXB and BXH recombinant inbred strains). 454 of the markers could be assigned to specific chromosomes, and the amount of genome covered by the mapped markers was estimated to be 1151 centimorgans. By including a variety of morphologic, biochemical, immunogenetic, and molecular markers, the current map integrates and extends existing linkage data and should facilitate rat gene mapping and genetic studies of hypertension and other complex phenotypes of interest in the HXB and BXH recombinant inbred strains.

Entities: Disease Species

Mesh：

Substances：
DNA Primers

Year: 1996 PMID： 8835528 DOI： 10.1007/s003359900031

Source DB: PubMed Journal: Mamm Genome ISSN： 0938-8990 Impact factor: 2.957

46 in total

Review 1. Use of recombinant inbred strains to identify quantitative trait loci in psychopharmacology.

Authors: G Gora-Maslak; G E McClearn; J C Crabbe; T J Phillips; J K Belknap; R Plomin
Journal: Psychopharmacology (Berl) Date: 1991 Impact factor: 4.530

Review 2. Empirical estimates of Bonferroni corrections for use in chromosome mapping studies with the BXD recombinant inbred strains.

Authors: J K Belknap
Journal: Behav Genet Date: 1992-11 Impact factor: 2.805

Review 3. Inference in linkage analysis of multifactorial traits using recombinant inbred strains of mice.

Authors: P E Neumann
Journal: Behav Genet Date: 1992-11 Impact factor: 2.805

Review 4. A Macintosh program for storage and analysis of experimental genetic mapping data.

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Journal: Mamm Genome Date: 1993 Impact factor: 2.957

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6. Genetic map of 12 polymorphic loci on rat chromosome 1.

Authors: E A Goldmuntz; E F Remmers; H Zha; J M Cash; P Mathern; L J Crofford; R L Wilder
Journal: Genomics Date: 1993-06 Impact factor: 5.736

7. Restriction fragment length polymorphism of hsp70 gene, localized in the RT1 complex, is associated with hypertension in spontaneously hypertensive rats.

Authors: P Hamet; D Kong; M Pravenec; J Kunes; V Kren; P Klir; Y L Sun; J Tremblay
Journal: Hypertension Date: 1992-06 Impact factor: 10.190

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Authors: G Vergnaud; D Mariat; F Apiou; A Aurias; M Lathrop; V Lauthier
Journal: Genomics Date: 1991-09 Impact factor: 5.736

10. Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt-sensitive rats.

Authors: Y Deng; J P Rapp
Journal: Nat Genet Date: 1992-07 Impact factor: 38.330

18 in total

1. Finding new human minisatellite sequences in the vicinity of long CA-rich sequences.

Authors: F Giraudeau; E Petit; H Avet-Loiseau; Y Hauck; G Vergnaud; V Amarger
Journal: Genome Res Date: 1999-07 Impact factor: 9.043

2. Rat chromosome 1: regional localization of seven genes (Slc9a3, Srd5a1, Esr, Tcp1, Grik5, Tnnt3, Jak2) and anchoring of the genetic linkage map to the cytogenetic map.

Authors: C Szpirer; J Szpirer; F Tissir; E Stephanova; P Vanvooren; T W Kurtz; N Iwai; T Inagami; M Pravenec; V Kren; K Klinga-Levan; G Levan
Journal: Mamm Genome Date: 1997-09 Impact factor: 2.957

3. A new framework marker-based linkage map and SDPs for the rat HXB/BXH strain set.

Authors: Martin Jirout; Drahomíra Krenová; Vladimír Kren; Laura Breen; Michal Pravenec; Nicholas J Schork; Morton P Printz
Journal: Mamm Genome Date: 2003-08 Impact factor: 2.957

4. Quantitative trait loci influencing cholesterol and phospholipid phenotypes map to chromosomes that contain genes regulating blood pressure in the spontaneously hypertensive rat.

Authors: A Bottger; H A van Lith; V Kren; D Krenová; V Bílá; J Vorlícek; V Zídek; A Musilová; M Zdobinská; J M Wang; B F van Zutphen; T W Kurtz; M Pravenec
Journal: J Clin Invest Date: 1996-08-01 Impact factor: 14.808

5. Chromosomal assignment of nineteen rat microsatellite markers to various chromosomes by linkage analysis.

Authors: V E Sverdlov; O I Dukhanina; C Choi; M T Bihoreau; H Dene; J P Rapp
Journal: Mamm Genome Date: 1998-03 Impact factor: 2.957

6. Chromosomal assignment of three rat and human H-rev genes, putative tumor suppressors, down-regulated in malignantly HRAS-transformed cells.

Authors: C Szpirer; J Szpirer; M Rivière; A Hajnal; M Kiess; B Scharm; R Schäfer
Journal: Mamm Genome Date: 1996-09 Impact factor: 2.957