BACKGROUND: Previous studies have suggested that cancers of the breast and prostate cluster in families and that the presence of both diseases in a family may be associated with increased risk of breast cancer. PURPOSE: Our purpose was to evaluate whether 1) prostate cancer aggregates in families with postmenopausal breast cancer, 2) families with cancers of the breast and prostate are the same ones as families with cancers of the breast and ovary, and 3) a family history of prostate cancer is associated with increased risk of postmenopausal breast cancer. METHODS: We analyzed data from a large prospective cohort study of Iowa women that were (at baseline) aged 55-69 years in 1986. At the third follow-up survey in 1992, self-reported data on family history of breast, ovarian, and prostate cancers in parents and siblings were provided by 30,883 women. Additional information was collected to ascertain whether the age-of-onset of breast cancer in mothers or sisters was before or after the age of 45 years. Cancer occurrence was documented using the State Health Registry of Iowa. RESULTS: History of prostate cancer in their father or a brother was reported by 3384 (11.0%) of the women, and a total of 4090 women (13.2%) reported breast cancer in their mother or a sister. A positive family history of both cancers was reported by 556 women, significantly (two-sided P < .001) greater than the 457 women expected if the family histories were independent. The aggregation of breast, prostate, and ovarian cancers was reported by 22 participants, greater than the 2.7 expected (two-sided P < .0001). During 6 years of follow-up, 578 breast cancers were identified in the cohort at risk. Compared with women without a family history of either cancer, women with a family history of breast cancer had a relative risk (RR) of 1.37 (95% confidence interval [CI] = 1.06-1.79) if the affected relative had onset after the age of 45 years, and an RR of 1.71 (95% CI = 1.13-2.61) if the affected relative had onset at or before the age of 45. A family history of prostate cancer in the absence of a family history of breast cancer was associated with an RR of 1.19 (95% CI = .90-1.56). However, a family history of both breast and prostate cancers was associated with RRs of 2.06 (95% CI = 1.23-3.45) and 2.35 (95% CI = .97-5.67) for breast cancer onset in relatives of greater than 45 and less than or equal to 45 years, respectively. CONCLUSIONS: These observations are concordant with recent reports that suggest a shared familial risk (inherited or environmental) for these hormone-dependent malignancies.
BACKGROUND: Previous studies have suggested that cancers of the breast and prostate cluster in families and that the presence of both diseases in a family may be associated with increased risk of breast cancer. PURPOSE: Our purpose was to evaluate whether 1) prostate cancer aggregates in families with postmenopausal breast cancer, 2) families with cancers of the breast and prostate are the same ones as families with cancers of the breast and ovary, and 3) a family history of prostate cancer is associated with increased risk of postmenopausal breast cancer. METHODS: We analyzed data from a large prospective cohort study of Iowa women that were (at baseline) aged 55-69 years in 1986. At the third follow-up survey in 1992, self-reported data on family history of breast, ovarian, and prostate cancers in parents and siblings were provided by 30,883 women. Additional information was collected to ascertain whether the age-of-onset of breast cancer in mothers or sisters was before or after the age of 45 years. Cancer occurrence was documented using the State Health Registry of Iowa. RESULTS: History of prostate cancer in their father or a brother was reported by 3384 (11.0%) of the women, and a total of 4090 women (13.2%) reported breast cancer in their mother or a sister. A positive family history of both cancers was reported by 556 women, significantly (two-sided P < .001) greater than the 457 women expected if the family histories were independent. The aggregation of breast, prostate, and ovarian cancers was reported by 22 participants, greater than the 2.7 expected (two-sided P < .0001). During 6 years of follow-up, 578 breast cancers were identified in the cohort at risk. Compared with women without a family history of either cancer, women with a family history of breast cancer had a relative risk (RR) of 1.37 (95% confidence interval [CI] = 1.06-1.79) if the affected relative had onset after the age of 45 years, and an RR of 1.71 (95% CI = 1.13-2.61) if the affected relative had onset at or before the age of 45. A family history of prostate cancer in the absence of a family history of breast cancer was associated with an RR of 1.19 (95% CI = .90-1.56). However, a family history of both breast and prostate cancers was associated with RRs of 2.06 (95% CI = 1.23-3.45) and 2.35 (95% CI = .97-5.67) for breast cancer onset in relatives of greater than 45 and less than or equal to 45 years, respectively. CONCLUSIONS: These observations are concordant with recent reports that suggest a shared familial risk (inherited or environmental) for these hormone-dependent malignancies.
Authors: Siddhartha P Kar; Jonathan Beesley; Ali Amin Al Olama; Kyriaki Michailidou; Jonathan Tyrer; ZSofia Kote-Jarai; Kate Lawrenson; Sara Lindstrom; Susan J Ramus; Deborah J Thompson; Adam S Kibel; Agnieszka Dansonka-Mieszkowska; Agnieszka Michael; Aida K Dieffenbach; Aleksandra Gentry-Maharaj; Alice S Whittemore; Alicja Wolk; Alvaro Monteiro; Ana Peixoto; Andrzej Kierzek; Angela Cox; Anja Rudolph; Anna Gonzalez-Neira; Anna H Wu; Annika Lindblom; Anthony Swerdlow; Argyrios Ziogas; Arif B Ekici; Barbara Burwinkel; Beth Y Karlan; Børge G Nordestgaard; Carl Blomqvist; Catherine Phelan; Catriona McLean; Celeste Leigh Pearce; Celine Vachon; Cezary Cybulski; Chavdar Slavov; Christa Stegmaier; Christiane Maier; Christine B Ambrosone; Claus K Høgdall; Craig C Teerlink; Daehee Kang; Daniel C Tessier; Daniel J Schaid; Daniel O Stram; Daniel W Cramer; David E Neal; Diana Eccles; Dieter Flesch-Janys; Digna R Velez Edwards; Dominika Wokozorczyk; Douglas A Levine; Drakoulis Yannoukakos; Elinor J Sawyer; Elisa V Bandera; Elizabeth M Poole; Ellen L Goode; Elza Khusnutdinova; Estrid Høgdall; Fengju Song; Fiona Bruinsma; Florian Heitz; Francesmary Modugno; Freddie C Hamdy; Fredrik Wiklund; Graham G Giles; Håkan Olsson; Hans Wildiers; Hans-Ulrich Ulmer; Hardev Pandha; Harvey A Risch; Hatef Darabi; Helga B Salvesen; Heli Nevanlinna; Henrik Gronberg; Hermann Brenner; Hiltrud Brauch; Hoda Anton-Culver; Honglin Song; Hui-Yi Lim; Iain McNeish; Ian Campbell; Ignace Vergote; Jacek Gronwald; Jan Lubiński; Janet L Stanford; Javier Benítez; Jennifer A Doherty; Jennifer B Permuth; Jenny Chang-Claude; Jenny L Donovan; Joe Dennis; Joellen M Schildkraut; Johanna Schleutker; John L Hopper; Jolanta Kupryjanczyk; Jong Y Park; Jonine Figueroa; Judith A Clements; Julia A Knight; Julian Peto; Julie M Cunningham; Julio Pow-Sang; Jyotsna Batra; Kamila Czene; Karen H Lu; Kathleen Herkommer; Kay-Tee Khaw; Keitaro Matsuo; Kenneth Muir; Kenneth Offitt; Kexin Chen; Kirsten B Moysich; Kristiina Aittomäki; Kunle Odunsi; Lambertus A Kiemeney; Leon F A G Massuger; Liesel M Fitzgerald; Linda S Cook; Lisa Cannon-Albright; Maartje J Hooning; Malcolm C Pike; Manjeet K Bolla; Manuel Luedeke; Manuel R Teixeira; Marc T Goodman; Marjanka K Schmidt; Marjorie Riggan; Markus Aly; Mary Anne Rossing; Matthias W Beckmann; Matthieu Moisse; Maureen Sanderson; Melissa C Southey; Michael Jones; Michael Lush; Michelle A T Hildebrandt; Ming-Feng Hou; Minouk J Schoemaker; Montserrat Garcia-Closas; Natalia Bogdanova; Nazneen Rahman; Nhu D Le; Nick Orr; Nicolas Wentzensen; Nora Pashayan; Paolo Peterlongo; Pascal Guénel; Paul Brennan; Paula Paulo; Penelope M Webb; Per Broberg; Peter A Fasching; Peter Devilee; Qin Wang; Qiuyin Cai; Qiyuan Li; Radka Kaneva; Ralf Butzow; Reidun Kristin Kopperud; Rita K Schmutzler; Robert A Stephenson; Robert J MacInnis; Robert N Hoover; Robert Winqvist; Roberta Ness; Roger L Milne; Ruth C Travis; Sara Benlloch; Sara H Olson; Shannon K McDonnell; Shelley S Tworoger; Sofia Maia; Sonja Berndt; Soo Chin Lee; Soo-Hwang Teo; Stephen N Thibodeau; Stig E Bojesen; Susan M Gapstur; Susanne Krüger Kjær; Tanja Pejovic; Teuvo L J Tammela; Thilo Dörk; Thomas Brüning; Tiina Wahlfors; Tim J Key; Todd L Edwards; Usha Menon; Ute Hamann; Vanio Mitev; Veli-Matti Kosma; Veronica Wendy Setiawan; Vessela Kristensen; Volker Arndt; Walther Vogel; Wei Zheng; Weiva Sieh; William J Blot; Wojciech Kluzniak; Xiao-Ou Shu; Yu-Tang Gao; Fredrick Schumacher; Matthew L Freedman; Andrew Berchuck; Alison M Dunning; Jacques Simard; Christopher A Haiman; Amanda Spurdle; Thomas A Sellers; David J Hunter; Brian E Henderson; Peter Kraft; Stephen J Chanock; Fergus J Couch; Per Hall; Simon A Gayther; Douglas F Easton; Georgia Chenevix-Trench; Rosalind Eeles; Paul D P Pharoah; Diether Lambrechts Journal: Cancer Discov Date: 2016-07-17 Impact factor: 39.397
Authors: Traci N Bethea; Lynn Rosenberg; Nelsy Castro-Webb; Kathryn L Lunetta; Lara E Sucheston-Campbell; Edward A Ruiz-Narváez; Marjory Charlot; Song-Yi Park; Elisa V Bandera; Melissa A Troester; Christine B Ambrosone; Julie R Palmer Journal: Cancer Epidemiol Biomarkers Prev Date: 2015-12-31 Impact factor: 4.254
Authors: Matthew B Clements; Emily A Vertosick; Lourdes Guerrios-Rivera; Amanda M De Hoedt; Javier Hernandez; Michael A Liss; Robin J Leach; Stephen J Freedland; Alexander Haese; Francesco Montorsi; Stephen A Boorjian; Cedric Poyet; Donna P Ankerst; Andrew J Vickers Journal: Eur Urol Date: 2021-12-31 Impact factor: 24.267
Authors: J Gudmundsson; G Johannesdottir; A Arason; J T Bergthorsson; S Ingvarsson; V Egilsson; R B Barkardottir Journal: Am J Hum Genet Date: 1996-04 Impact factor: 11.025
Authors: Jennifer L Beebe-Dimmer; Cecilia Yee; Michele L Cote; Nancie Petrucelli; Nynikka Palmer; Cathryn Bock; Dorothy Lane; Ilir Agalliu; Marcia L Stefanick; Michael S Simon Journal: Cancer Date: 2015-03-09 Impact factor: 6.860
Authors: Lauren Barber; Travis Gerke; Sarah C Markt; Samuel F Peisch; Kathryn M Wilson; Thomas Ahearn; Edward Giovannucci; Giovanni Parmigiani; Lorelei A Mucci Journal: Clin Cancer Res Date: 2018-08-06 Impact factor: 12.531
Authors: A Vazina; J Baniel; Y Yaacobi; A Shtriker; D Engelstein; I Leibovitz; M Zehavi; A A Sidi; Y Ramon; T Tischler; P M Livne; E Friedman Journal: Br J Cancer Date: 2000-08 Impact factor: 7.640